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Comment
. 2023 Jan 30;8(1):45.
doi: 10.1038/s41392-023-01328-4.

The cGAS-STING pathway: a therapeutic target in chromosomally unstable cancers

Haiyan Yan  1 , Weiguo Lu  2   3 , Fangwei Wang  4   5   6
Affiliations
Comment

The cGAS-STING pathway: a therapeutic target in chromosomally unstable cancers

Haiyan Yan et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The cGAS-STING pathway drives IL-6-STAT3 signaling to enable survival of chromosomally unstable cancers. The viability of cancer cells with CIN relies on the balance between STAT1 and STAT3 signaling downstream of cGAS-STING. Inhibition of IL-6 signaling by the clinically used blocking antibody tocilizumab selectively reduces the survival of cancer cells experiencing CIN
See this image and copyright information in PMC

Comment on

  • cGAS-STING drives the IL-6-dependent survival of chromosomally instable cancers.
    Hong C, Schubert M, Tijhuis AE, Requesens M, Roorda M, van den Brink A, Ruiz LA, Bakker PL, van der Sluis T, Pieters W, Chen M, Wardenaar R, van der Vegt B, Spierings DCJ, de Bruyn M, van Vugt MATM, Foijer F. Hong C, et al. Nature. 2022 Jul;607(7918):366-373. doi: 10.1038/s41586-022-04847-2. Epub 2022 Jun 15. Nature. 2022. PMID: 35705809

References

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