Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Mar;128(5):705-706.
doi: 10.1038/s41416-023-02173-6. Epub 2023 Jan 30.

Comment on 'Use the term "infiltrative" instead of "replacement" when defining histopathological growth pattern in patients with liver cancer' by Kong B et al

Peter Vermeulen  1 , Emily Latacz  2 , Laura Hendrickx  2 , Michelle Van den Hauwe  2 , Luc Dirix  2
Affiliations
Comment

Comment on 'Use the term "infiltrative" instead of "replacement" when defining histopathological growth pattern in patients with liver cancer' by Kong B et al

Peter Vermeulen et al. Br J Cancer. 2023 Mar.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Haematoxylin- and eosin-stained tissue section of a breast cancer liver metastasis with a replacement histopathological growth pattern (scale bar: 50 µm).
At the metastasis-liver interface, hepatocytes are gradually replaced by cancer cells and flattened, atrophic hepatocytes (yellow dots) can be observed in between the cancer cells and the sinusoidal blood vessels. Towards the centre of the metastasis (top of the image), the hepatocyte remnants are no longer present. The co-opted sinusoidal blood vessels largely retain their parallel arrangement as in the adjacent liver (green arrows). The distance between these blood vessels is increased by the proliferation of the cancer cells. Typically, these replacement-type metastases have many mitotic figures, some of which are marked with a white circle. Also typically, only few immune cells are present. M metastasis, L liver.
See this image and copyright information in PMC

Comment on

References

    1. Kong B, Zhang Q, Zhang G. Use the term “infiltrative” instead of “replacement” when defining histopathological growth pattern in patients with liver cancer. Br J Cancer. 2023 (this issue). - PMC - PubMed
    1. Latacz E, Höppener D, Bohlok A, Leduc S, Tabariès S, Fernández Moro C, et al. Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights. Br J Cancer. 2022;127:988–1013. doi: 10.1038/s41416-022-01859-7. - DOI - PMC - PubMed
    1. Vermeulen PB, Colpaert C, Salgado R, Royers R, Hellemans H, Van Den Heuvel E, et al. Liver metastases from colorectal adenocarcinomas grow in three patterns with different angiogenesis and desmoplasia. J Pathol. 2001;195:336–42. doi: 10.1002/path.966. - DOI - PubMed
    1. Bohlok A, Vermeulen P, Leduc S, Latacz E, Botzenhart L, Richard F, et al. Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients. npj Breast Cancer. 2020;6:64. doi: 10.1038/s41523-020-00209-1. - DOI - PMC - PubMed
    1. Bridgeman VL, Vermeulen PB, Foo S, Bilecz A, Daley F, Kostaras E, et al. Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models. J Pathol. 2017;241:362–74. doi: 10.1002/path.4845. - DOI - PMC - PubMed