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Review
. 2023 Apr;47(4):714-719.
doi: 10.1002/cbin.11991. Epub 2023 Jan 30.

Human umbilical cord mesenchymal stem cells: Heralding an effective treatment against esophageal cancer?

Reza ArefNezhad  1 , Fatemeh Rezaei-Tazangi  2 , Hossein Roghani-Shahraki  3 , Pouya Goleij  4   5 , Nabi Zare  1 , Hossein Motedayyen  6 , Elaheh Aghazadeh  7   8
Affiliations
Review

Human umbilical cord mesenchymal stem cells: Heralding an effective treatment against esophageal cancer?

Reza ArefNezhad et al. Cell Biol Int. 2023 Apr.

Abstract

Esophageal cancer (EC), as one of the leading causes of cancer-associated mortality, influences a remarkable population of subjects globally and is histologically divided into two types, comprising esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). Although several therapeutic approaches are present for EC, such as radiotherapy, chemotherapy, and surgery, these options have low success with serious side effects, for example, gastrointestinal toxicity, esophagitis, and pulmonary complications. Thus, utilizing an effective tool with low side effects is urgent. Newly, mesenchymal stem cells (MSCs) have received special interest for treating diverse diseases, such as cancer. Among different sources of MSCs, human umbilical cord MSCs have notable benefits, and reports expressed that they may be effective in EC treatment. For this purpose, in this review study, we aimed to summarize evidence regarding the effects of human umbilical cord MSCs on EC with a mechanistic insight.

Keywords: esophageal cancer; mesenchymal stem cells; umbilical cord.

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References

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