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Case Reports
. 1987;8(2):179-90.
doi: 10.1016/0891-4222(87)90002-3.

Naltrexone in treatment of self injurious behavior: a clinical study

L Szymanski  1 , J Kedesdy, S Sulkes, A Cutler, P Stevens-Our
Affiliations
Case Reports

Naltrexone in treatment of self injurious behavior: a clinical study

L Szymanski et al. Res Dev Disabil. 1987.

Abstract

It has been suggested that the parenteral opiate antagonist, naloxone, might ameliorate self-injurious behavior. However, clinical studies have had conflicting results. We have evaluated whether a potent oral opiate antagonist, naltrexone, is effective in the treatment of this condition. The study was conducted on two young, profoundly mentally retarded adults, who exhibited intractable self-injurious behavior. A double-blind, placebo-controlled, within-subject-withdrawal design was utilized. One subject was studied for 12 weeks and the other one for 18 weeks. No measurable effects on the self-injurious behavior were observed.

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