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. 2023 Jan 21:25:100415.
doi: 10.1016/j.phro.2023.100415. eCollection 2023 Jan.

Assessment of intra-fraction motion during frameless image guided Gamma Knife stereotactic radiosurgery

Winnie Li  1   2 , Gregory Bootsma  1 , David Shultz  1   2 , Normand Laperriere  1   2 , Barbara-Ann Millar  1   2 , Young Bin Cho  1   2 , David A Jaffray  1   2 , Caroline Chung  1   2 , Catherine Coolens  1   2
Affiliations

Assessment of intra-fraction motion during frameless image guided Gamma Knife stereotactic radiosurgery

Winnie Li et al. Phys Imaging Radiat Oncol. .

Abstract

As frameless stereotactic radiosurgery increase in use, the aim of this study was to evaluate intra-fraction motion through cone-beam CT (CBCT) and high-definition motion management (HDMM) systems. Intra-fraction motion measured between localization, repeat localization and post-treatment CBCTs were correlated to intra-faction motion indicated by the HDMM files using the Pearson coefficient (r). A total of 302 plans were reviewed from 263 patients (114 male, 149 female); 216 pairs of localization-repeat localization, and 260 localization-post-treatment CBCTs were analyzed against HDMM logs. We found the magnitude of intra-fraction motion detected by the HDMM system were larger than the corresponding CBCT results.

Keywords: Gamma Knife; Image guidance; Intrafraction motion; Stereotactic radiosurgery.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: This work was partially supported through a research grant from Elekta and the Canadian Institutes of Health Research (CIHR); the principal investigators of the grants were Dr. David Jaffray and Dr. Caroline Chung.

Figures

Fig. 1
Fig. 1
A) the intra-fraction vector magnitude detected by the hdmm system, and b) the intra-fraction vector magnitude measured on cbcts. c) a scatterplot of cbct magnitude vs hdmm magnitude is shown, triaged between post (localization – post-treatment) and repeat (localization – repeat localization) pairs. a linear model was created to relate the hdmm magnitude to cbct magnitudes. the model was selected to find a hdmm value for which at least 96% of the cbct magnitude values will be less than some ratio of that hdmm value plus a constant, allowing for an accurate selection of a hdmm trigger value.
See this image and copyright information in PMC

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