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. 2023 Apr;38(4):692-697.
doi: 10.1002/mds.29334. Epub 2023 Jan 31.

Christmas-Related Reduction in Beta Activity in Parkinson's Disease

Lucia K Feldmann  1   2 , Roxanne Lofredi  1   2 , Bassam Al-Fatly  1 , Johannes L Busch  1 , Varvara Mathiopoulou  1 , Jan Roediger  1   3 , Patricia Krause  1 , Gerd-Helge Schneider  4 , Katharina Faust  4 , Andreas Horn  5   6   7   8 , Andrea A Kühn  1   9   10   11 , Wolf-Julian Neumann  1   3
Affiliations

Christmas-Related Reduction in Beta Activity in Parkinson's Disease

Lucia K Feldmann et al. Mov Disord. 2023 Apr.

Abstract

Background: Subthalamic nucleus (STN) beta (13 - 35 Hz) activity is a biomarker reflecting motor state in Parkinson's disease (PD). Adaptive deep brain stimulation (DBS) aims to use beta activity for therapeutic adjustments, but many aspects of beta activity in real-life situations are unknown.

Objective: The aim was to investigate Christmas-related influences on beta activity in PD.

Methods: Differences in Christmas Day to nonfestive daily averages in chronic biomarker recordings in 4 PD patients with a sensing-enabled STN DBS implant were retrospectively analyzed. Sweet-spot and whole-brain network connectomic analyses were performed.

Results: Beta activity was significantly reduced on Christmas Eve in all patients (4.00-9.00 p.m.: -12.30 ± 10.78%, P = 0.015). A sweet spot in the dorsolateral STN connected recording sites to motor, premotor, and supplementary motor cortices.

Conclusions: We demonstrate that festive events can reduce beta biomarker activity. We conclude that circadian and holiday-related changes should be considered when tailoring adaptive DBS algorithms to patient demands. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keywords: Parkinson's disease; adaptive deep brain stimulation; basal ganglia; movement disorders; neurophysiology.

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References

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    1. Feldmann LK, Lofredi R, Neumann WJ, et al. Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings. npj Parkinson's Dis 2022;8(1):44.

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