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Review
. 2023 Apr 1;36(2):74-80.
doi: 10.1097/QCO.0000000000000905. Epub 2023 Jan 30.

Skin and soft tissue infections due to rapidly growing mycobacteria

Chiara Sepulcri  1 , Antonio Vena  1   2 , Matteo Bassetti  1   2
Affiliations
Review

Skin and soft tissue infections due to rapidly growing mycobacteria

Chiara Sepulcri et al. Curr Opin Infect Dis. .

Abstract

Purpose of review: The aim of this article is to review skin and soft tissue infections due to rapidly growing mycobacteria (RGM), with a particular focus on recently published literature (2021-2022).

Recent findings: RGM are increasingly reported as a cause of skin and soft tissue infections, both in the community setting and as a cause of nosocomial outbreaks. Recent advances in molecular methods have expanded the number of species of RGM and resulted in increased diagnosis. New treatment options are under evaluation particularly for Mycobacterium abscessus , the most difficult-to-treat among RGM.

Summary: RGM are an uncommon cause of skin and soft tissue infections and a high clinical suspicion together with advanced laboratory facilities are required for diagnosis. Species identification and antimicrobial susceptibility testing are essential to drive appropriate treatment, which combines surgical debridement with prolonged antimycobacterial combination therapy.

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References

    1. Brown-Elliott BA, Wallace RJ. Clinical and taxonomic status of pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria. Clin Microbiol Rev 2002; 15:716–746.
    1. Brown-Elliott BA, Philley JV. Rapidly growing mycobacteria. Schlossberg D, editor. Microbiol Spectr 2017. 5.1.02.
    1. Cheng Y, Lei W, Wang X, et al. Mycolicibacterium baixiangningiae sp. nov. and Mycolicibacterium mengxianglii sp. nov., two new rapidly growing mycobacterial species. Int J Syst Evolution Microbiol 2021; 71:
    1. Philley JV, Griffith DE. Griffith DE. Disease caused by Mycobacterium abscessus and other rapidly growing mycobacteria (RGM). Nontuberculous mycobacterial disease. Cham: Springer International Publishing; 2019. 369–399. (Respiratory Medicine).
    1. Falkinham JO. Environmental sources of nontuberculous mycobacteria. Clin Chest Med 2015; 36:35–41.

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