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Review
. 2023;123(1):16-27.
doi: 10.17116/jnevro202312301116.

[Oxidative stress in the pathogenesis of stroke and its correction]

[Article in Russian]
M Yu Martynov  1   2 , M V Zhuravleva  3   4 , N S Vasyukova  5 , E V Kuznetsova  6 , T R Kameneva  7
Affiliations
Review

[Oxidative stress in the pathogenesis of stroke and its correction]

[Article in Russian]
M Yu Martynov et al. Zh Nevrol Psikhiatr Im S S Korsakova. 2023.

Abstract
in English, Russian

We reviewed the role of oxidative stress (OS) in the pathogenesis of ischemic (IS) and hemorrhagic stroke (HS). OS plays a major role in programmed cell death, increased permeability of the blood-brain barrier, astroglial and microglial activation, and local inflammatory response. We also reviewed the current state of neuro- and cytoprotection studies and their translation in clinical practice. With respect to experimental and clinical data the efficacy of long term administration of multimodal cytoprotective drug with antioxidant effect - ethylmethylhydroxypyridine succinate (Mexidol) is discussed during the acute and early recovery period after stroke.

Рассмотрено значение окислительного стресса (ОС) в патогенезе ишемического (ИИ) и геморрагического (ГИ) инсульта. Показана роль ОС в развитии программируемой клеточной смерти, повышении проницаемости гематоэнцефалического барьера, активации астро- и микроглии, локального воспаления. Рассмотрены вопросы нейро- и цитопротекции и их трансляции в клиническую практику. На примерах экспериментальных и клинических исследований показана эффективность продолженного назначения мультимодального нейроцитопротектора с антиоксидантным действием — этилметилгидроксипиридина сукцината (Мексидол) в остром и раннем восстановительном периодах ИИ и ГИ.

Keywords: Mexidol; apoptosis; ethylmethylhydroxypyridine succinate; ferroptosis; hemoglobin; neuroprotection; oxidative stress; programmed cell death; reperfusion; stroke.

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