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Comment
. 2023 Jan 1;34(1):175.
doi: 10.1681/ASN.0000000000000018.

A Crystal-Independent Role for Uric Acid in AKI Associated with Tumor Lysis Syndrome

Abutaleb A Ejaz  1   2 , Rajesh Mohandas  3 , Thomas M Beaver  3 , Richard J Johnson  4
Affiliations
Comment

A Crystal-Independent Role for Uric Acid in AKI Associated with Tumor Lysis Syndrome

Abutaleb A Ejaz et al. J Am Soc Nephrol. .
No abstract available

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Conflict of interest statement

R.J. Johnson has equity with XORT Therapeutics, which is developing novel xanthine oxidase inhibitors, is an inventor on several patents on the role of uric acid in hypertension, metabolic syndrome, and diabetic nephropathy that resulted from research (US Patent Nos. 7,799,794; 8,236,488; 8,557,831; 9,155,740 B), and has consulted for AstraZeneca, Danone Research Foundation, and Horizon Pharmaceuticals. R.J. Johnson also reports Ownership Interest: Colorado Research Partners LLC (founder shares); Research Funding: NIH, Veteran's Administration; Honoraria: Horizon Pharmaceutical, Universities; Patents or Royalties: Comprehensive Clinical Nephrology (Elsevier) and Nature Wants Us to Be Fat (BenBella). T. Beaver reports Consultancy: Jace orthopedics; Ownership Interest: Rivian, Lucid, Shockwave, Exxon, Carnival, Norwegian, Disney, Genuine Parts, Amazon; Research Funding: Surgical Site PI for valve trials, Edwards, Medtronic, Abbot; and Advisory or Leadership Role: Atricure Inc Scientific Advisory for IST trial. All remaining authors have nothing to disclose.

Comment in

Comment on

  • Tumor Lysis Syndrome and AKI: Beyond Crystal Mechanisms.
    Arnaud M, Loiselle M, Vaganay C, Pons S, Letavernier E, Demonchy J, Fodil S, Nouacer M, Placier S, Frère P, Arrii E, Lion J, Mooney N, Itzykson R, Djediat C, Puissant A, Zafrani L. Arnaud M, et al. J Am Soc Nephrol. 2022 Jun;33(6):1154-1171. doi: 10.1681/ASN.2021070997. Epub 2022 May 6. J Am Soc Nephrol. 2022. PMID: 35523579 Free PMC article.

References

    1. Arnaud M Loiselle M Vaganay C, et al. . Tumor lysis syndrome and AKI: beyond crystal mechanisms. J Am Soc Nephrol. 2022;33(6):1154-1171. doi:10.1681/asn.2021070997 - DOI - PMC - PubMed
    1. Roncal CA Mu W Croker B, et al. . Effect of elevated serum uric acid on cisplatin-induced acute renal failure. Am J Physiol Renal Physiol. 2007;292(1):F116-F122. doi:10.1152/ajprenal.00160.2006 - DOI - PubMed
    1. Ejaz AA Johnson RJ Shimada M, et al. . The role of uric acid in acute kidney injury. Nephron. 2019;142(4):275-283. doi:10.1159/000499939 - DOI - PubMed
    1. Ejaz AA Dass B Lingegowda V, et al. . Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery. Int Urol Nephrol. 2013;45(2):449-458. doi:10.1007/s11255-012-0192-2 - DOI - PubMed

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