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. 2023 Feb 1;133(3):e165446.
doi: 10.1172/JCI165446.

Comprehensive analysis of HIV reservoirs in elite controllers

Brooke D Kennedy  1 , Jana Blazkova  1 , Jesse S Justement  1 , Victoria Shi  1 , M Ali Rai  1 , Maegan R Manning  1 , Lauren Praiss  1 , Kathleen Gittens  2 , Paul A Wender  3 , Sean Patro  4 , Xiaolin Wu  4 , Susan Moir  1 , Tae-Wook Chun  1
Affiliations

Comprehensive analysis of HIV reservoirs in elite controllers

Brooke D Kennedy et al. J Clin Invest. .
No abstract available

Keywords: AIDS/HIV; Molecular biology; T cells; Virology.

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Conflict of interest statement

Conflict of interest: The authors have declared that no conflict of interest exists.

Figures

Figure 1
Figure 1. HIV reservoirs and immune responses.
(A) Total HIV DNA and cell-associated HIV RNA, TBP, TATA-binding protein, (B) intact proviral and defective DNA, (C) virion-associated HIV RNA and replication-competent virus, (D) ratios of intact-to-defective and intact proviral DNA to replication-competent virus, and (E) HIV-specific immune responses between the EC and CA groups. Open symbols indicate values under limits of detection. Black bars represent the geometric mean or median values. P values were determined using the Mann-Whitney test and were not adjusted. (F) Measurements of intact proviral DNA and inducible virion-associated HIV RNA as well as composition of intact and defective HIV DNA in EC-4. (G) Percentage of CD4+ T cell subsets and distribution of intact and defective HIV DNA within each subset in EC-6. n = total DNA copy numbers/106 CD4+ T cells. Sequence alignment of HIV DNA is shown.
See this image and copyright information in PMC

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