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Review
. 2023 Jan 31;40(3):86.
doi: 10.1007/s12032-023-01958-2.

Wnt3a is a promising target in colorectal cancer

Muhammad Tufail  1 , Changxin Wu  2
Affiliations
Review

Wnt3a is a promising target in colorectal cancer

Muhammad Tufail et al. Med Oncol. .

Abstract

Most colorectal cancers (CRC) are associated with activated Wnt signaling, making it the fourth most prevalent type of cancer globally. To function properly, the Wnt signaling pathway requires secreted glycoproteins known as Wnt ligands (Wnts). Humans have 19 Wnts, which suggest a complicated signaling and biological process, and we still know little about their functions in developing CRC. This review aims to describe the canonical Wnt signaling in CRC, particularly the Wnt3a expression pattern, and their association with the angiogenesis and progression of CRC. This review also sheds light on the inhibition of Wnt3a signaling in CRC. Despite some obstacles, a thorough understanding of Wnts is essential for effectively managing CRC.

Keywords: Angiogenesis; Chemoresistance; Colorectal cancer; Wnt pathway; Wnt3a.

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