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Review
. 2023 Mar:116:109781.
doi: 10.1016/j.intimp.2023.109781. Epub 2023 Jan 29.

Characteristics and pathogenesis of chemokines in the post-stroke stage

Yu-Ting Lin  1 , Hao-Dong Chen  1 , Qi-di Ai  1 , Yan-Tao Yang  1 , Zhao Zhang  2 , Shi-Feng Chu  3 , Nai-Hong Chen  4
Affiliations
Review

Characteristics and pathogenesis of chemokines in the post-stroke stage

Yu-Ting Lin et al. Int Immunopharmacol. 2023 Mar.

Abstract

Chemokines, as small molecular proteins, play a crucial role in the immune and inflammatory responses after stroke. A large amount of evidence showed chemokines and their receptors were increasingly recognized as potential targets for stroke treatment, which were involved in the processing of neovascularization, neurogenesis, and neural network reconstruction. In this review, we summarized the characteristics of chemokine alterations throughout the post-stroke nerve repair phase to gain insight into the pathological mechanisms of chemokines and find effective therapeutic targets for stroke.

Keywords: Chemokine; Chemokine receptor; Nerve repair; Stroke.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.