Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies

doi:10.1002/ptr.7737

Review

. 2023 Apr;37(4):1462-1487.

doi: 10.1002/ptr.7737. Epub 2023 Jan 31.

Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies

Hajar Heidari¹, Mohammad Bagherniya², Muhammed Majeed³, Thozhukat Sathyapalan⁴, Tannaz Jamialahmadi^{5

6}, Amirhossein Sahebkar^{6

7

8

9}

Affiliations

¹ Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
² Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Sabinsa Corporation, East Windsor, New Jersey, USA.
⁴ Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, United Kingdom.
⁵ Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁶ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
⁷ Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁸ School of Medicine, The University of Western Australia, Perth, Western Australia, Australia.
⁹ Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 36720711
DOI: 10.1002/ptr.7737

Review

Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies

Hajar Heidari et al. Phytother Res. 2023 Apr.

. 2023 Apr;37(4):1462-1487.

doi: 10.1002/ptr.7737. Epub 2023 Jan 31.

Authors

Hajar Heidari¹, Mohammad Bagherniya², Muhammed Majeed³, Thozhukat Sathyapalan⁴, Tannaz Jamialahmadi^{5

6}, Amirhossein Sahebkar^{6

7

8

9}

Affiliations

¹ Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
² Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Sabinsa Corporation, East Windsor, New Jersey, USA.
⁴ Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, United Kingdom.
⁵ Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁶ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
⁷ Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁸ School of Medicine, The University of Western Australia, Perth, Western Australia, Australia.
⁹ Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 36720711
DOI: 10.1002/ptr.7737

Abstract

Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti-inflammatory and anti-oxidant activities. Despite its safety and potential for use against various diseases, curcumin's utility is restricted due to its low oral bioavailability. Co-administration of curcumin along with piperine could potentially improve the bioavailability of curcumin. The present review aimed to provide an overview of the efficacy and safety of curcumin-piperine co-supplementation in human health. The findings of this comprehensive review show the beneficial effects of curcumin-piperine in improving glycemic indices, lipid profile and antioxidant status in diabetes, improving the inflammatory status caused by obesity and metabolic syndrome, reducing oxidative stress and depression in chronic stress and neurological disorders, also improving chronic respiratory diseases, asthma and COVID-19. Further high-quality clinical trial studies are needed to firmly establish the clinical efficacy of the curcumin-piperine supplement.

Keywords: clinical; curcumin; health; piperine; preclinical.

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References

REFERENCES

1. Aggarwal, B. B., & Sung, B. (2009). Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets. Trends in Pharmacological Sciences, 30(2), 85-94.
1. Ahmad, N., Fazal, H., Abbasi, B. H., Farooq, S., Ali, M., & Khan, M. A. (2012). Biological role of Piper nigrum L.(black pepper): A review. Asian Pacific Journal of Tropical Biomedicine, 2(3), S1945-S1953.
1. Alidadi, M., Jamialahmadi, T., Cicero, A. F. G., Bianconi, V., Pirro, M., Banach, M., & Sahebkar, A. (2020). The potential role of plant-derived natural products in improving arterial stiffness: A review of dietary intervention studies. Trends in Food Science and Technology, 99, 426-440. https://doi.org/10.1016/j.tifs.2020.03.026
1. Alikiaii, B., Bagherniya, M., Askari, G., Johnston, T. P., & Sahebkar, A. (2021). The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective. BioFactors, 47(1), 19-40.
1. Alikiaii, B., Bagherniya, M., Askari, G., Sathyapalan, T., & Sahebkar, A. (2021). Evaluation of the effect of curcumin on pneumonia: A systematic review of preclinical studies. Phytotherapy Research, 35(4), 1939-1952.

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[1] Aggarwal, B. B., & Sung, B. (2009). Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets. Trends in Pharmacological Sciences, 30(2), 85-94.

[2] Aggarwal, B. B., & Sung, B. (2009). Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets. Trends in Pharmacological Sciences, 30(2), 85-94.

[3] Ahmad, N., Fazal, H., Abbasi, B. H., Farooq, S., Ali, M., & Khan, M. A. (2012). Biological role of Piper nigrum L.(black pepper): A review. Asian Pacific Journal of Tropical Biomedicine, 2(3), S1945-S1953.

[4] Ahmad, N., Fazal, H., Abbasi, B. H., Farooq, S., Ali, M., & Khan, M. A. (2012). Biological role of Piper nigrum L.(black pepper): A review. Asian Pacific Journal of Tropical Biomedicine, 2(3), S1945-S1953.

[5] Alidadi, M., Jamialahmadi, T., Cicero, A. F. G., Bianconi, V., Pirro, M., Banach, M., & Sahebkar, A. (2020). The potential role of plant-derived natural products in improving arterial stiffness: A review of dietary intervention studies. Trends in Food Science and Technology, 99, 426-440. https://doi.org/10.1016/j.tifs.2020.03.026

[6] Alidadi, M., Jamialahmadi, T., Cicero, A. F. G., Bianconi, V., Pirro, M., Banach, M., & Sahebkar, A. (2020). The potential role of plant-derived natural products in improving arterial stiffness: A review of dietary intervention studies. Trends in Food Science and Technology, 99, 426-440. https://doi.org/10.1016/j.tifs.2020.03.026

[7] Alikiaii, B., Bagherniya, M., Askari, G., Johnston, T. P., & Sahebkar, A. (2021). The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective. BioFactors, 47(1), 19-40.

[8] Alikiaii, B., Bagherniya, M., Askari, G., Johnston, T. P., & Sahebkar, A. (2021). The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective. BioFactors, 47(1), 19-40.

[9] Alikiaii, B., Bagherniya, M., Askari, G., Sathyapalan, T., & Sahebkar, A. (2021). Evaluation of the effect of curcumin on pneumonia: A systematic review of preclinical studies. Phytotherapy Research, 35(4), 1939-1952.

[10] Alikiaii, B., Bagherniya, M., Askari, G., Sathyapalan, T., & Sahebkar, A. (2021). Evaluation of the effect of curcumin on pneumonia: A systematic review of preclinical studies. Phytotherapy Research, 35(4), 1939-1952.

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Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies

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Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies

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