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. 2023 Jan 31;13(1):1736.
doi: 10.1038/s41598-023-27993-7.

Production of zirconium-88 via proton irradiation of metallic yttrium and preparation of target for neutron transmission measurements at DICER

Artem V Matyskin  1   2 , Athanasios Stamatopoulos  3 , Ellen M O'Brien  4 , Brad J DiGiovine  3   5 , Veronika Mocko  4 , Michael E Fassbender  4 , C Etienne Vermeulen  4 , Paul E Koehler  3
Affiliations

Production of zirconium-88 via proton irradiation of metallic yttrium and preparation of target for neutron transmission measurements at DICER

Artem V Matyskin et al. Sci Rep. .

Abstract

A process for the production of tens to hundreds of GBq amounts of zirconium-88 (88Zr) using proton beams on yttrium was developed. For this purpose, yttrium metal targets (≈20 g) were irradiated in a ~16 to 34 MeV proton beam at a beam current of 100-200 µA at the Los Alamos Isotope Production Facility (IPF). The 88Zr radionuclide was produced and separated from the yttrium targets using hydroxamate resin with an elution yield of 94(5)% (1σ). Liquid DCl solution in D2O was selected as a suitable 88Zr sample matrix due to the high neutron transmission of deuterium compared to hydrogen and an even distribution of 88Zr in the sample matrix. The separated 88Zr was dissolved in DCl and 8 µL of the obtained solution was transferred to a tungsten sample can with a 1.2 mm diameter hole using a syringe and automated filling station inside a hot cell. Neutron transmission of the obtained 88Zr sample was measured at the Device for Indirect Capture Experiments on Radionuclides (DICER).

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
(a) Experimental literature data,– (points) and model predicted TENDL 2019 data (dotted line) for the 89Y(p,2n)88Zr cross section and the predicted Y target energy window (gray). (b) Experimental literature data,–, (points) and model predicted TENDL 2019 data (dotted line) for the 89Y(p,x)88Y cross section and the predicted Y target energy window (gray).
Figure 2
Figure 2
Elution profile for 88Zr on a hydroxamate column (2 g). Error bars correspond to 1σ standard deviation calculated from duplicates.
Figure 3
Figure 3
Amount of Zr extracted into CCl4 as a function of TTA or TBP concentration in CCl4 from 1 mol·L−1 HNO3 (TTA) and 5 mol·L−1 HNO3 (TBP).
Figure 4
Figure 4
Measured DICER and ENDF neutron transmission through TTA/CCl4 natZr target: 8 µL of CCl4 sample with 0.3 mol·L−1 TTA with 1.4 µg of natZr and Pb windows. Error bars correspond to 1σ.
Figure 5
Figure 5
Measured DICER and ENDF neutron transmission through DCl/D2O natZr target: 8 µL of 2 mol·L−1 DCl in D2O (with 99.95% D atoms) and 1.4 µg of natZr and Pb windows. Error bars correspond to 1σ.
Figure 6
Figure 6
Design of the zirconium-88 sample can used for the neutron transmission measurements at DICER.
Figure 7
Figure 7
Automated station for transferring of 8 µL sample with 88Zr.
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