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Case Reports
. 2022 Dec 30;14(12):e33135.
doi: 10.7759/cureus.33135. eCollection 2022 Dec.

Lamotrigine-Induced Acute Pancreatitis

Emad Elmusa  1 , Muhammad Waleed Raza  1 , Ahmad Muneeb  1 , Ameer Hamza  1 , Mujtaba Butt  2
Affiliations
Case Reports

Lamotrigine-Induced Acute Pancreatitis

Emad Elmusa et al. Cureus. .

Abstract

Drug-induced pancreatitis is a rare phenomenon. Therefore, diagnosis requires ruling out more common etiologies of acute pancreatitis. The majority of research on drug-induced pancreatitis is from case reports. Only a limited number of drugs have been definitively established to induce pancreatitis. Lamotrigine is used in both bipolar and epilepsy. Lamotrigine is currently weakly identified to induce pancreatitis. We present a case of lamotrigine-induced pancreatitis. Extensive workup ruled out other major causes of pancreatitis-including alcohol. We aimed to show lamotrigine can be a causative drug of acute pancreatitis.

Keywords: ct; drug-induced pancreatitis; lamotrigine; mri; pancreatitis; ultrasound; valproic acid.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Ultrasound with hypoechoic pancreas consistent with acute pancreatitis.
Figure 2
Figure 2. Upper abdominal CT scan without contrast shows peripancreatic edema consistent with acute pancreatitis.
Figure 3
Figure 3. Diffusion restriction within the distal body and pancreatic tail of the pancreas is noted on upper abdominal MRI.
See this image and copyright information in PMC

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