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Case Reports
. 2023 Jan 26;11(1):e6697.
doi: 10.1002/ccr3.6697. eCollection 2023 Jan.

Differentiation syndrome in patients with acute promyelocytic leukemia

Nusiba H Elamin  1 , Farah Rashid  1 , Muhammad S Afana  2 , Honar Cherif  2 , Mohamed A Yassin  2
Affiliations
Case Reports

Differentiation syndrome in patients with acute promyelocytic leukemia

Nusiba H Elamin et al. Clin Case Rep. .

Abstract

A 48-year-old male diagnosed with acute promyelocytic leukemia (APL) started on all-trans-retinoic acid and arsenic trioxide, developed typical symptoms of differentiation syndrome, and improved dramatically on steroids. Hence, any APL patient started on chemotherapy, needs to be monitored closely for developing differentiation syndrome and to start steroid upon suspicion.

Keywords: ATRA syndrome; acute leukemia; steroids.

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Conflict of interest statement

The authors declare that there was conflict no of interest regarding the publication of this case report.

Figures

FIGURE 1
FIGURE 1
Bilateral opacities extending laterally in a fan shape from the hilum
FIGURE 2
FIGURE 2
Resolution of the bilateral opacities as complare to previous chest X‐ray
See this image and copyright information in PMC

References

    1. Ibrahim FA, Yassin MA, El Ayoubi HR, et al. Clinico‐pathological profile of acute promyelocytic leukaemia at Al‐Amal oncology‐Haematology Centre, Qatar. East Mediterr Health J. 2010;16(9):958‐965. - PubMed
    1. Stahl M, Tallman MS. Differentiation syndrome in acute promyelocytic leukaemia. Br J Haematol. 2019;187(2):157‐162. - PubMed

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