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Review
. 2023 Jun;53(6):e13962.
doi: 10.1111/eci.13962. Epub 2023 Feb 8.

Secondary prevention after intracerebral haemorrhage

Maddalena Toffali  1 , Federico Carbone  2   3 , Enrico Fainardi  4 , Andrea Morotti  5 , Fabrizio Montecucco  2   3 , Luca Liberale  2   3 , Alessandro Padovani  1   5
Affiliations
Review

Secondary prevention after intracerebral haemorrhage

Maddalena Toffali et al. Eur J Clin Invest. 2023 Jun.

Abstract

Background: Intracerebral haemorrhage (ICH) has high mortality in the acute phase and poor functional outcome in the majority of survivors. ICH recurrence is a major determinant of long-term prognosis and is the most feared complication of antithrombotic treatment. On the other hand, ICH patients are at high risk of future ischaemic vascular events.

Methods: This narrative review provides a critical analysis of the current knowledge on the topic. We performed a Pubmed search with the following terms 'intracerebral haemorrhage', 'stroke', 'outcome', 'secondary prevention', 'anticoagulation' and 'atrial fibrillation', including only English written studies with no time restrictions.

Results: Blood pressure management is the cornerstone of secondary ICH prevention, regardless of ICH location or underlying cerebral small vessel disease. Resumption of antiplatelet and anticoagulation therapy is often challenging, with limited evidence from randomized trials. Clinical and imaging predictors can inform the stratification of ICH recurrence risk and might identify patients at very high probability of future haemorrhagic events. This narrative review provides a summary of the main diagnostic tools and therapeutic strategies available for secondary prevention in ICH survivors.

Conclusion: Appropriate recognition and treatment of modifiable risk factors for ICH recurrence might improve outcomes in ICH survivors. Ongoing randomized trials might provide novel insights and improve long-term management.

Keywords: anticoagulation; atrial fibrillation; intracerebral haemorrhage; outcome; secondary prevention; stroke.

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References

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