S3 Guideline Urticaria. Part 1: Classification and diagnosis of urticaria - German-language adaptation of the international S3 Guideline

Torsten Zuberbier^{1

2}, Sabine Altrichter³, Sabine Bauer⁴, Randolf Brehler⁵, Knut Brockow⁶, Corinna Dressler⁷, Joachim Fluhr^{1

2}, Matthew Gaskins⁷, Eckard Hamelmann⁸, Kathrin Kühne⁴, Hans Merk⁹, Norbert K Mülleneisen¹⁰, Alexander Nast⁷, Heidi Olze¹¹, Hagen Ott¹², Marc Pleimes¹³, Franziska Ruëff¹⁴, Petra Staubach-Renz¹⁵, Bettina Wedi¹⁶, Marcus Maurer^{1

2}

Affiliations

¹ Charité - Universitätsmedizin Berlin, Institute of Allergology, Berlin, Germany.
² Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
³ University Hospital for Dermatology und Venereology, Comprehensive Allergy Center, Kepler University Hospital, Linz, Austria.
⁴ Urtikaria-Helden e.V., Koblenz, Germany.
⁵ Center for Skin Diseases, University Hospital Münster, Department of Dermatology, Münster, Germany.
⁶ Department und Clinic for Dermatology und Allergology am Biederstein, Technical University of Munich, Munich, Germany.
⁷ Division of Evidence-Based Medicine, Department for Dermatology, Venereology und Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
⁸ Department for Pediatric and Adolescent Medinine, Evangelisches Klinikum Bethel, University Hospital OWL, University of Bielefeld, Bielefeld, Germany.
⁹ Department for Dermatology und Allergology, University Hospital RTWH Aachen, Aachen, Germany.
¹⁰ Asthma and Allergies Center, Leverkusen, Germany.
¹¹ Department of Ear, Nose and Throat Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
¹² Hospital for Pediatric and Adolescent Medicine Auf der Bult, Hannover, Germany.
¹³ Practice for Pediatric and Adolescent Dermatology, Heidelberg, Germany.
¹⁴ Department and Clinic for Dermatology und Allergology, LMU Hospital at the University of Munich, Munich, Germany.
¹⁵ Department and Clinic for Skin Diseases, University Hospital at Johannes Gutenberg University Mainz, Mainz, Germany.
¹⁶ Hannover Medical School Dept. of Dermatology and Allergology, Hannover, Germany.

PMID: 36721941
DOI: 10.1111/ddg.14906

Practice Guideline

S3 Guideline Urticaria. Part 1: Classification and diagnosis of urticaria - German-language adaptation of the international S3 Guideline

Torsten Zuberbier et al. J Dtsch Dermatol Ges. 2023 Jan.

. 2023 Jan;21(1):81-93.

doi: 10.1111/ddg.14906.

Authors

Affiliations

¹ Charité - Universitätsmedizin Berlin, Institute of Allergology, Berlin, Germany.
² Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
³ University Hospital for Dermatology und Venereology, Comprehensive Allergy Center, Kepler University Hospital, Linz, Austria.
⁴ Urtikaria-Helden e.V., Koblenz, Germany.
⁵ Center for Skin Diseases, University Hospital Münster, Department of Dermatology, Münster, Germany.
⁶ Department und Clinic for Dermatology und Allergology am Biederstein, Technical University of Munich, Munich, Germany.
⁷ Division of Evidence-Based Medicine, Department for Dermatology, Venereology und Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
⁸ Department for Pediatric and Adolescent Medinine, Evangelisches Klinikum Bethel, University Hospital OWL, University of Bielefeld, Bielefeld, Germany.
⁹ Department for Dermatology und Allergology, University Hospital RTWH Aachen, Aachen, Germany.
¹⁰ Asthma and Allergies Center, Leverkusen, Germany.
¹¹ Department of Ear, Nose and Throat Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
¹² Hospital for Pediatric and Adolescent Medicine Auf der Bult, Hannover, Germany.
¹³ Practice for Pediatric and Adolescent Dermatology, Heidelberg, Germany.
¹⁴ Department and Clinic for Dermatology und Allergology, LMU Hospital at the University of Munich, Munich, Germany.
¹⁵ Department and Clinic for Skin Diseases, University Hospital at Johannes Gutenberg University Mainz, Mainz, Germany.
¹⁶ Hannover Medical School Dept. of Dermatology and Allergology, Hannover, Germany.

PMID: 36721941
DOI: 10.1111/ddg.14906

Abstract

The lifetime prevalence of urticaria, a severe allergic disease, is almost 20%. It not only limits the quality of life of those affected, but also their general performance at work and in their daily activities. This publication is the first section of the Urticaria Guideline. It covers the classification and diagnosis of urticaria, taking into account the major advances in research into its causes, triggering factors and pathomechanisms. It also addresses strategies for the efficient diagnosis of the different subtypes of urticaria. This is crucial for individual, patient-oriented treatment, which is covered in the second part of the guideline, published separately. This German-language guideline was developed according to the criteria of the AWMF on the basis of the international English-language S3 guideline with special consideration of health system characteristics in the German-speaking countries. This first part of the guideline describes the classification of urticaria, distinguishing spontaneously occurring wheals (hives) and angioedema from forms of urticaria with inducible symptoms. Urticaria is defined as sudden onset of wheals, angioedema, or both, but is to be distinguished from conditions in which wheals occur as a short-term symptom, such as anaphylaxis. The diagnosis is based on (a limited number of) laboratory tests, but especially on medical history. In addition, validated instruments are available to measure the severity, activity and course of the disease.

Keywords: angioedema; diagnostics; guideline; urticaria; wheal.

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References

REFERENCES

1. Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al. The international EAACI/GA2LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2021; 77(3):734-766.
1. Guyatt G, Oxman AD, Akl EA, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64(4):383-394.
1. Kaminski-Hartenthaler A, Meerpohl JJ, Gartlehner G, et al. GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations. Z Evid Fortbild Qual Gesundhwes. 2014;108(7):413-420.
1. Church MK, Kolkhir P, Metz M, Maurer M. The role and relevance of mast cells in urticaria. Immunol Rev. 2018;282(1):232-247.
1. Haas N, Schadendorf D, Henz BM. Differential endothelial adhesion molecule expression in early and late whealing reactions. Int Arch Allergy Immunol. 1998;115(3):210-214.

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S3 Guideline Urticaria. Part 1: Classification and diagnosis of urticaria - German-language adaptation of the international S3 Guideline

Affiliations

S3 Guideline Urticaria. Part 1: Classification and diagnosis of urticaria - German-language adaptation of the international S3 Guideline

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical