Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr 1;51(2):51-56.
doi: 10.1249/JES.0000000000000313. Epub 2023 Feb 1.

Controlling Inflammation Improves Aging Skeletal Muscle Health

William A Fountain  1 , Masatoshi Naruse, Alex Claiborne, Scott Trappe, Todd A Trappe
Affiliations

Controlling Inflammation Improves Aging Skeletal Muscle Health

William A Fountain et al. Exerc Sport Sci Rev. .

Abstract

Chronic inflammation is associated with a decline in aging skeletal muscle health. Inflammation also seems to interfere with the beneficial skeletal muscle adaptations conferred by exercise training in older individuals. We hypothesize that the cyclooxygenase pathway is partially responsible for this negative inflammatory influence on aging skeletal muscle health and plasticity.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Proposed contribution of the COX pathway to the effect of inflammation on aging skeletal muscle. The authors hypothesize that the effect of age-related inflammation (i.e., “inflammaging”) on the development of sarcopenia can be mitigated by reducing the contribution of the COX pathway in aging skeletal muscle. Similarly, it appears the influence of age-related inflammation on limiting exercise adaptations can be mitigated by reducing the contribution of the COX pathway, ultimately promoting greater improvements in skeletal muscle health.
Figure 2.
Figure 2.
Overview of the PGE2 portion of the COX pathway (i.e., the PGE2/COX pathway) in skeletal muscle and the proposed series of reactions and downstream regulatory events that influence skeletal muscle mass. Aging and muscle fiber type alter the level of COX pathway components. See text for the studies and specific references that have delineated the items outlined in this schematic. PLA2, phospholipase A2; COX, cyclooxygenase; PGH2, prostaglandin H2; PGE2, prostaglandin E2; MuRF-1, muscle RING finger 1; IL-6, interleukin 6.
See this image and copyright information in PMC

References

    1. Scott A, Khan KM, Cook JL, and V D. What is “inflammation”? Are we ready to move beyond Celsus? Brit J Sport Med 38: 248–249, 2004. - PMC - PubMed
    1. Wallach D, Kang T-B, and Kovalenko A. Concepts of tissue injury and cell death in inflammation: a historical perspective. Nat Rev Immunol 14: 51–59, 2014. - PubMed
    1. Elisia I, Lam V, Hofs E, Li M, Hay M, Cho B, Brooks-Wilson A, Rosin M, Bu L, Jia W, and Krystal G. Effect of age on chronic inflammation and responsiveness to bacterial and viral challenges. PLoS One 12: e0188881, 2017. - PMC - PubMed
    1. Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy D, Fasano A, Miller G, Miller A, Mantovani A, Weyand C, Barzilai N, Goronzy J, Rando T, Effros R, Lucia A, Kleinstreuer N, and Slavich G. Chronic inflammation in the etiology of disease across the life span. Nat Med 25: 1822–1832, 2019. - PMC - PubMed
    1. Germolec D, Shipowski K, Frawley R, and Evans E. Markers of inflammation. In: Immunotoxicity Testing Methods in Molecular Biology. New York, NY: Humana Press, 2018, p. 57–79. - PubMed

Publication types