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Review
. 2023 Dec;45(1):2171887.
doi: 10.1080/0886022X.2023.2171887.

Advances in imaging techniques to assess kidney fibrosis

Affiliations
Review

Advances in imaging techniques to assess kidney fibrosis

Buchun Jiang et al. Ren Fail. 2023 Dec.

Abstract

As a sign of chronic kidney disease (CKD) progression, renal fibrosis is an irreversible and alarming pathological change. The accurate diagnosis of renal fibrosis depends on the widely used renal biopsy, but this diagnostic modality is invasive and can easily lead to sampling error. With the development of imaging techniques, an increasing number of noninvasive imaging techniques, such as multipara meter magnetic resonance imaging (MRI) and ultrasound elastography, have gained attention in assessing kidney fibrosis. Depending on their ability to detect changes in tissue stiffness and diffusion of water molecules, ultrasound elastography and some MRI techniques can indirectly assess the degree of fibrosis. The worsening of renal tissue oxygenation and perfusion measured by blood oxygenation level-dependent MRI and arterial spin labeling MRI separately is also an indirect reflection of renal fibrosis. Objective and quantitative indices of fibrosis may be available in the future by using novel techniques, such as photoacoustic imaging and fluorescence microscopy. However, these imaging techniques are susceptible to interference or may not be convenient. Due to the lack of sufficient specificity and sensitivity, these imaging techniques are neither widely accepted nor proposed by clinicians. These obstructions must be overcome by conducting technology research and more prospective studies. In this review, we emphasize the recent advancement of these noninvasive imaging techniques and provide clinicians a continuously updated perspective on the assessment of kidney fibrosis.

Keywords: Imaging techniques; kidney fibrosis; magnetic resonance imaging; ultrasound elastography.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
The pathological foundation of imaging techniques to assess kidney fibrosis. BOLD-MRI: Blood oxygenation level-dependent MRI; ASL-MRI: Arterial spin labeling MRI; SE: strain elastography; SWE: shear wave elastography; MRE: magnetic resonance elastography; PAI: photoacoustic imaging; ECM: extracellular matrix; MTI: magnetization transfer imaging; DWI: diffusion weighted imaging; DTI: diffusion tensor imaging; IVIM: intravoxel incoherent motion imaging; DKI: diffusion kurtosis imaging. The increase and deposition of ECM lead to the increase of kidney stiffness and macromolecule content, meanwhile, decrease the tissue oxygenation and perfusion, restrict the diffusion of water molecules. This pathologic change is the foundation of different imaging techniques to assess kidney fibrosis.

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