A loosely coordinated interaction site for arachidonic acid on ASICs
- PMID: 36723670
- PMCID: PMC9929933
- DOI: 10.1085/jgp.202213307
A loosely coordinated interaction site for arachidonic acid on ASICs
Abstract
Molecular dynamics simulations reveal a putative interaction surface for PUFAs on TM1 of ASICs that is not tightly conserved between isoforms.
Comment on
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Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains.J Gen Physiol. 2023 Mar 6;155(3):e202213259. doi: 10.1085/jgp.202213259. Epub 2023 Jan 10. J Gen Physiol. 2023. PMID: 36625864 Free PMC article.
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