GOT1 constrains T_H17 cell differentiation, while promoting iT_reg cell differentiation

Wei Xu^{1

2}, Chirag H Patel^{1

3}, Jesse Alt⁴, Liang Zhao¹, Im-Hong Sun¹, Min-Hee Oh⁵, Im-Meng Sun¹, Jiayu Wen¹, Richard L Blosser¹, Ada J Tam¹, Jonathan D Powell^{6

7}

Affiliations

¹ Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney-Kimmel Comprehensive Cancer Research Center, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
² Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
³ Calico, San Francisco, CA, USA.
⁴ Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁵ Department of Immunobiology, Yale University, New Haven, CT, USA.
⁶ Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney-Kimmel Comprehensive Cancer Research Center, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. poweljo@jhmi.edu.
⁷ Calico, San Francisco, CA, USA. poweljo@jhmi.edu.

Comment

Wei Xu et al. Nature. 2023 Feb.

. 2023 Feb;614(7946):E1-E11.

doi: 10.1038/s41586-022-05602-3. Epub 2023 Feb 1.

Wei Xu^{1

2}, Chirag H Patel^{1

3}, Jesse Alt⁴, Liang Zhao¹, Im-Hong Sun¹, Min-Hee Oh⁵, Im-Meng Sun¹, Jiayu Wen¹, Richard L Blosser¹, Ada J Tam¹, Jonathan D Powell^{6

7}

¹ Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney-Kimmel Comprehensive Cancer Research Center, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
² Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
³ Calico, San Francisco, CA, USA.
⁴ Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁵ Department of Immunobiology, Yale University, New Haven, CT, USA.
⁶ Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney-Kimmel Comprehensive Cancer Research Center, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. poweljo@jhmi.edu.
⁷ Calico, San Francisco, CA, USA. poweljo@jhmi.edu.

No abstract available

Comment in

Reply to: GOT1 constrains T_H17 cell differentiation, while promoting iT_reg cell differentiation.
Xu T, Qin Z, Wang X, Dong C, Driggers EM, Ding S. Xu T, et al. Nature. 2023 Feb;614(7946):E12-E14. doi: 10.1038/s41586-022-05603-2. Nature. 2023. PMID: 36725991 No abstract available.

Metabolic control of T_H17 and induced T_reg cell balance by an epigenetic mechanism.
Xu T, Stewart KM, Wang X, Liu K, Xie M, Ryu JK, Li K, Ma T, Wang H, Ni L, Zhu S, Cao N, Zhu D, Zhang Y, Akassoglou K, Dong C, Driggers EM, Ding S. Xu T, et al. Nature. 2017 Aug 10;548(7666):228-233. doi: 10.1038/nature23475. Epub 2017 Aug 2. Nature. 2017. PMID: 28783731 Free PMC article.

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