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. 2023 Jan 26:17:385-390.
doi: 10.2147/OPTH.S393519. eCollection 2023.

Reported Rates of Intraocular Inflammation with Intravitreal Aflibercept Administered via Pre-Filled Syringe or from Vials in Clinical Practice Between 2012 and 2022

Ursula Schmidt-Ott  1 , Scott Fitzpatrick  2 , Zoran Hasanbasic  3 , Sergio Leal  3 , Peter Morgan-Warren  4 , Xin Zhang  3 , Kristian T Johnson  5
Affiliations

Reported Rates of Intraocular Inflammation with Intravitreal Aflibercept Administered via Pre-Filled Syringe or from Vials in Clinical Practice Between 2012 and 2022

Ursula Schmidt-Ott et al. Clin Ophthalmol. .

Abstract

Purpose: To determine the reported rates of intraocular inflammation (IOI) in patients treated with intravitreal aflibercept (IVT-AFL) 2 mg in routine clinical practice (ie, outside interventional studies), across all indications and within all countries (excluding the United States), with access to either the vial presentation or pre-filled syringe (PFS).

Patients and methods: A search was conducted using the Bayer EYLEA® Global Safety Pharmacovigilance Database for reported cases of IOI and IVT-AFL use between October 2012 and March 31, 2022.

Results: With more than 10 years of post-marketing experience with the IVT-AFL vial presentation (>25 million sold units), and over 2 years of experience with the PFS of IVT-AFL (>6.7 million sold units) the rate of any IOI, including endophthalmitis, outside the United States was 0.3 events per 10,000 units for the PFS and 1.2 events per 10,000 units for the vial presentation. The event rates specifically for endophthalmitis were 0.1 per 10,000 units for the IVT-AFL PFS and 0.6 per 10,000 units for the IVT-AFL vial presentation.

Conclusion: In patients with retinal diseases treated in routine clinical practice with IVT-AFL either from a vial or the PFS, medically important adverse events of IOI, and in particular, endophthalmitis, are infrequently reported events. Numerically, reported rates of IOI and endophthalmitis are low for the vial presentation and even lower for the PFS.

Keywords: IOI; anti-VEGF; drug-related side effects and adverse reactions; eye; injection.

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Conflict of interest statement

All authors are salaried employees of, and hold stock options or own stock in, Bayer companies. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Ten most commonly reported terms related to intraocular inflammatory events with the intravitreal aflibercept vial or prefilled syringe between October 2012 and March 31, 2022.
See this image and copyright information in PMC

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