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Review
. 2023 Jan 16:13:1102471.
doi: 10.3389/fimmu.2022.1102471. eCollection 2022.

The immune suppressive tumor microenvironment in multiple myeloma: The contribution of myeloid-derived suppressor cells

Claudia Giannotta  1 , Federica Autino  1 , Massimo Massaia  1   2
Affiliations
Review

The immune suppressive tumor microenvironment in multiple myeloma: The contribution of myeloid-derived suppressor cells

Claudia Giannotta et al. Front Immunol. .

Abstract

Myeloid derived suppressors cells (MDSC) play major roles in regulating immune homeostasis and immune responses in many conditions, including cancer. MDSC interact with cancer cells within the tumor microenvironment (TME) with direct and indirect mechanisms: production of soluble factors and cytokines, expression of surface inhibitory molecules, metabolic rewiring and exosome release. The two-way relationship between MDSC and tumor cells results in immune evasion and cancer outgrowth. In multiple myeloma (MM), MDSC play a major role in creating protumoral TME conditions. In this minireview, we will discuss the interplay between MDSC and MM TME and the possible strategies to target MDSC.

Keywords: Immunothearpies; MDSC (myeloid-derived suppressor cell); TME (tumor microenvironment); immune suppression; multiple myeloma.

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Conflict of interest statement

MM reports advisory boards for AbbVie, Janssen-Cilag, Sanofi, and research funding from Sanofi. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be constructed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Myeloma cell and surrounding cells promote MDSC differentiation and suppressive functions. In turn, MDSC undermine anti-tumor immune responses and guarantee myeloma cells survival and growth. Red arrows: direct mechanisms; blue arrows: indirect mechanisms. Created by BioRender.com.
See this image and copyright information in PMC

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