Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 19;32(1):1-10.
doi: 10.1055/s-0042-1750184. eCollection 2023 Mar.

Effects of Moderate Intensity Aerobic Exercise to FSTL-1 Regulation in Atherosclerosis: A Systematic Review

Vito Anggarino Damay  1 , Setiawan Setiawan  2 , Ronny Lesmana  2 , Muhammad Rizki Akbar  3 , Antonia Anna Lukito  1
Affiliations
Review

Effects of Moderate Intensity Aerobic Exercise to FSTL-1 Regulation in Atherosclerosis: A Systematic Review

Vito Anggarino Damay et al. Int J Angiol. .

Abstract

Moderate intensity exercise is considered as a primary step to prevent coronary artery diseases (CADs) by stimulated FSTL-1 secretion as a novel myokines to improve endothelial cell function, prevent arterial stiffness, or vascular inflammation. This review aims to provide the current evident role of FSTL-1 as a novel myokine secreted during exercise to prevent atherosclerosis progression. A systematic review using databases from (PubMed), ScienceDirect, and The Cochrane Library, was conducted up to October 2021 to identify all the eligible experimental and observational studies that assess how moderate intensity exercises stimulate FSTL-1 secretion to prevent atherosclerosis. Results were described through narrative synthesis of the evidence. From 84 retrieved references, 15 studies met the inclusion criteria and were included in this review. The overall results suggest that exercise or physical activity can stimulate myokines secretion, especially in FSTL-1. FSTL-1 is a myokine or adipokine that plays a potential role in preventing atherosclerosis by various mechanisms such as via improvement of endothelial functions, suppression of smooth muscle cells (SMCs) proliferation, and reduction of arterial thickening. FSTL-1 is a relatively new and less known myokine, but probably holds a key role in assessing how moderate intensity aerobic exercise prevents atherosclerosis progression by preventing endothelial dysfunction, arterial stiffness, or vascular inflammation.

Keywords: FSTL-1; atherosclerosis; coronary artery disease; moderate-intensity aerobic exercise; myokine.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest None declared.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram of study selection. PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
Fig. 2
Fig. 2
Several factors induce atherosclerosis progression and role of moderate intensity aerobic exercise.
See this image and copyright information in PMC

References

    1. Sianturi E T, Kurniawaty E. Pengaruh Pektin terhadap Penurunan Risiko Penyakit Jantung Koroner. Majority. 2019;8:162–167.
    1. Damay V A, Fathini F. Clinical Research Hubungan Rasio Lingkar Pinggang Bagi Tinggi Badan (Lp / Tb) Medicinus. 2016;6:7–13.
    1. Alfarisi H AH, Mohamed Z BH, Ibrahim M. Bin. Basic pathogenic mechanisms of atherosclerosis. Egypt. J Basic Appl Sci. 2020;7:116–125.
    1. Kirichenko T V, Sukhorukov V N, Markin A M. Medicinal plants as a potential and successful treatment option in the context of atherosclerosis. Front Pharmacol. 2020;11:403. - PMC - PubMed
    1. Winzer E B, Woitek F, Linke A. Physical activity in the prevention and treatment of coronary artery disease. J Am Heart Assoc. 2018;7(04):1–15. - PMC - PubMed