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. 2023 Mar 1;118(3):574-577.
doi: 10.14309/ajg.0000000000002192. Epub 2023 Jan 20.

Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease

Francesco Valitutti  1   2 , Maureen M Leonard  3   4 , Victoria Kenyon  3   4 , Monica Montuori  5 , Pasqua Piemontese  6 , Ruggiero Francavilla  7 , Basilio Malamisura  8 , Lorenzo Norsa  9 , Angela Calvi  10 , Maria Elena Lionetti  11 , Mariella Baldassarre  12 , Chiara Maria Trovato  13 , Michela Perrone  6 , Tiziana Passaro  8 , Naire Sansotta  9 , Marco Crocco  10 , Annalisa Morelli  14 , Lidia Celeste Raguseo  7 , Federica Malerba  10 , Luca Elli  15 , Fernanda Cristofori  7 , Carlo Catassi  11 , Alessio Fasano  2   3   4 ; CD-GEMM Team
Affiliations

Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease

Francesco Valitutti et al. Am J Gastroenterol. .

Abstract

Introduction: The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk.

Methods: A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity).

Results: Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion.

Discussion: Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.

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Conflict of interest statement

Conflict of interest: all authors declare no conflicts of interests relevant for this paper.

Figures

Figure 1:
Figure 1:
Study subgroups as per diagnostic outcomes. Eligible children from CDGEMM cohort who had at least three blood draws assessing both IgG aDGPs and anti-tTG IgA over consecutive timepoints. * CDA for research protocol are those who did not fulfill the ESPGHAN non-biopsy criteria and are awaiting biopsy confirmation or whose parents denied the recommended endoscopy needed to complete CD diagnosis.
Figure 2:
Figure 2:
Area Under the ROC Curve (AUC) for “predictive” aDGPs IgG among CD spectrum children and among CD children.
See this image and copyright information in PMC

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