Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar 1;42(3):261-271.
doi: 10.1097/ICO.0000000000003193. Epub 2022 Dec 19.

Novel Treatments for Chronic Ocular Surface Pain

Simran Mangwani-Mordani  1   2 , Courtney F Goodman  2 , Anat Galor  1   2
Affiliations

Novel Treatments for Chronic Ocular Surface Pain

Simran Mangwani-Mordani et al. Cornea. .

Abstract

Several etiologies can contribute to ocular surface pain including nociceptive, peripheral neuropathic, and central neuropathic mechanisms. Clinical clues can help identify contributors to ocular surface pain in a patient. In individuals whose pain persists despite targeting nociceptive contributors, neuropathic mechanisms should be considered and addressed using oral, topical, and/or adjuvant agents.

Trial registration: ClinicalTrials.gov NCT05424549 NCT05109702 NCT05238597 NCT04139798 NCT01252160 NCT03113448 NCT01557010 NCT00986882 NCT02961062 NCT04630158 NCT05310422.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Diagnosis and management of nociceptive causes of pain Footnotes DM: Diabetes Mellitus; HTN: Hypertension; PTSD: Post-traumatic stress disorder; TBUT: Tear Break Up Time.
Figure 2:
Figure 2:
Diagnosis and management of peripheral and central neuropathic pain Footnotes BID: Twice a day; OU: both eyes; ASTs: Autologous serum tears; PRGF: Plasma rich in growth factors; TRPV1: Transient Receptor Potential Vanilloid-1; TRPM8: Transient Receptor Potential Melastatin 8; TNS: Trigeminal nerve stimulation; SGB: Stellate ganglion block, SPG: Sphenopalatine ganglion.
*Figure 3:
*Figure 3:
Treatment options for nociceptive and neuropathic ocular pain Footnotes *This figure was created with biorender.com
See this image and copyright information in PMC

References

    1. IASP terminology. http://www.iasp-pain.org/Education/Content.aspx?ItemNumber=1698. Accessed June 2022.
    1. Pouyeh B, Viteri E, Feuer W, et al. Impact of ocular surface symptoms on quality of life in a United States veterans affairs population. Am J Ophthalmol 2012;153(6):1061–66 e3. - PubMed
    1. Kalangara JP, Galor A, Levitt RC, et al. Characteristics of Ocular Pain Complaints in Patients With Idiopathic Dry Eye Symptoms. Eye Contact Lens 2017;43(3):192–8. - PMC - PubMed
    1. Mehra D, Cohen NK, Galor A. Ocular Surface Pain: A Narrative Review. Ophthalmol Ther 2020;9(3):1–21. - PMC - PubMed
    1. Dermer H, Lent-Schochet D, Theotoka D, et al. A Review of Management Strategies for Nociceptive and Neuropathic Ocular Surface Pain. Drugs 2020;80(6):547–71. - PubMed

Associated data