Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Mar:326:199057.
doi: 10.1016/j.virusres.2023.199057. Epub 2023 Feb 3.

Role of genetic factors in different swine breeds exhibiting varying levels of resistance/susceptibility to PRRSV

Xiangbin You  1 , Gan Li  1 , Ying Lei  1 , Zhiqian Xu  1 , Ping Zhang  1 , Youbing Yang  2
Affiliations
Review

Role of genetic factors in different swine breeds exhibiting varying levels of resistance/susceptibility to PRRSV

Xiangbin You et al. Virus Res. 2023 Mar.

Abstract

Porcine reproductive and respiratory syndrome (PRRS), caused by the PRRS virus (PRRSV), is an economically significant contagious disease. Traditional approaches based on vaccines or medicines were challenging to control PRRSV due to the diversity of viruses. Different breeds of pigs infected with PRRSV have been reported to have different immune responses. However, due to the complexity of interaction mechanism between host and PRRSV, the genetic mechanism leading to PRRSV susceptibility/resistance in various pig breeds is still unclear. Herein, the role of host genetic components in PRRSV susceptibility is systematically described, and the molecular mechanisms by which host genetic factors such as SNPs, cytokines, receptor molecules, intestinal flora, and non-coding RNAs regulate PRRSV susceptibility/resistance. Therefore, improving the resistance to disease of individual animals through disease-resistance breeding technology is of profound significance for uplifting the sustainable and healthy development of the pig industry.

Keywords: Gut microbiota; Non-coding RNAs; PRRSV; Pig; Receptor; Resistance/susceptibility; SNPs.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Potential molecular mechanisms in PRRSV-resistant and PRRSV-susceptible pigs.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ait-Ali T., Wilson A.D., Westcott D.G., Clapperton M., Waterfall M., Mellencamp M.A., Drew T.W., Bishop S.C., Archibald A.L. Innate immune responses to replication of porcine reproductive and respiratory syndrome virus in isolated Swine alveolar macrophages. Viral Immunol. 2007;20:105–118. - PubMed
    1. An T.Q., Tian Z.J., He Y.X., Xiao Y., Jiang Y.F., Peng J.M., Zhou Y.J., Liu D., Tong G.Z. Porcine reproductive and respiratory syndrome virus attachment is mediated by the N-terminal domain of the sialoadhesin receptor. Vet. Microbiol. 2010;143:371–378. - PubMed
    1. Anastasiadou E., Jacob L.S., Slack F.J. Non-coding RNA networks in cancer. Nat. Rev. Cancer. 2018;18:5–18. - PMC - PubMed
    1. Bao H., Li X. Emergence and spread of NADC34-like PRRSV in China. Transbound. Emerg. Dis. 2021;68:3005–3008. - PubMed
    1. Bates J.S., Petry D.B., Eudy J., Bough L., Johnson R.K. Differential expression in lung and bronchial lymph node of pigs with high and low responses to infection with porcine reproductive and respiratory syndrome virus. J. Anim. Sci. 2008;86:3279–3289. - PubMed

Publication types

MeSH terms

LinkOut - more resources