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. 2023 Mar;44(3):268-270.
doi: 10.3174/ajnr.A7782. Epub 2023 Feb 2.

Edge-Enhancing Gradient-Echo MP2RAGE for Clinical Epilepsy Imaging at 7T

S Tao  1 , X Zhou  2 , E Greco  2 , V Gupta  2 , B E Freund  3 , E M Westerhold  2 , A M Feyissa  3 , W O Tatum  3 , S Grewal  4 , V Patel  2 , E H Middlebrooks  2   4
Affiliations

Edge-Enhancing Gradient-Echo MP2RAGE for Clinical Epilepsy Imaging at 7T

S Tao et al. AJNR Am J Neuroradiol. 2023 Mar.

Abstract

The 3D edge-enhancing gradient-echo (EDGE) MR imaging sequence offers superior contrast-to-noise ratio in the detection of focal cortical dysplasia. EDGE could benefit from 7T MR imaging but also faces challenges such as image inhomogeneity and low acquisition efficiency. We propose an EDGE-MP2RAGE sequence that can provide both EDGE and T1-weighted contrast, simultaneously, improving data-acquisition efficiency. We demonstrate that with sequence optimization, EDGE images with sufficient uniformity and T1-weighted images with high gray-to-white matter contrast can be achieved.

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Figures

FIG 1.
FIG 1.
Examples of WM and GM longitudinal magnetizations (Mz) evolution in a repetition period (TR) for the EDGE (A) and EDGE-MP2RAGE (B) sequences. With EDGE contrast (A), the center of the data-acquisition window, which coincides with the k-space center (ie, k = 0), is placed when WM and GM have comparable signal intensity but opposite polarity. With EDGE-MP2RAGE (B), the first acquisition (ie, INV 1) is designed to provide the EDGE contrast. A.U. indicates arbitrary unit.
FIG 2.
FIG 2.
Examples of EDGE (INV 1, A–C) images and T1-weighted (T1w) images (D–F) acquired with the EDGE-MP2RAGE reformatted into sagittal, axial, and coronal planes. The ROI (red circles in A–C) for WM and GM signal intensity measurements are also shown.
See this image and copyright information in PMC

References

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