Multicenter Study
doi: 10.1016/j.ejso.2023.01.010.
Epub 2023 Jan 20.
Practice variation in anastomotic leak after esophagectomy: Unravelling differences in failure to rescue
Sander Ubels
1
, Eric Matthée
2
, Moniek Verstegen
3
, Bastiaan Klarenbeek
3
, Stefan Bouwense
4
, Mark I van Berge Henegouwen
5
, Freek Daams
6
, Jan Willem T Dekker
7
, Marc J van Det
8
, Stijn van Esser
7
, Ewen A Griffiths
9
, Jan Willem Haveman
10
, Grard Nieuwenhuijzen
11
, Peter D Siersema
12
, Bas Wijnhoven
13
, Gerjon Hannink
14
, Frans van Workum
2
, Camiel Rosman
3
; TENTACLE – Esophagus collaborative group; Writing Committee; Joos Heisterkamp
15
, Fatih Polat
16
, Jeroen Schouten
17
, Pritam Singh
18
; Study collaborators
Collaborators,
Affiliations
Collaborators
-
Cettela A M Slootmans 17 , Gijs Ultee 17 , Suzanne S Gisbertz 19 , Wietse J Eshuis 19 , Marianne C Kalff 19 , Minke L Feenstra 19 , Donald L van der Peet 20 , Wessel T Stam 20 , Boudewijn Van Etten 21 , Floris Poelmann 21 , Nienke Vuurberg 21 , Jan Willem van den Berg 21 , Ingrid S Martijnse 15 , Robert M Matthijsen 15 , Misha Luyer 22 , Wout Curvers 22 , Tom Nieuwenhuijzen 22 , Annick E Taselaar 23 , Ewout A Kouwenhoven 24 , Merel Lubbers 24 , Meindert Sosef 25 , Frederik Lecot 25 , Tessa C M Geraedts 25 , Frits van den Wildenberg 16 , Wendy Kelder 26 , Merel Lubbers 26 , Peter C Baas 26 , Job W A de Haas 26 , Henk H Hartgrink 27 , Renu R Bahadoer 27 , Johanna W van Sandick 28 , Koen J Hartemink 28 , Xander Veenhof 28 , Hein Stockmann 29 , Burak Gorgec 29 , Pepijn Weeder 29 , Marinus J Wiezer 30 , Charlotte M S Genders 30 , Eric Belt 31 , Bjorn Blomberg 31 , Peter van Duijvendijk 32 , Linda Claassen 32 , David Reetz 32 , Pascal Steenvoorde 33 , Walter Mastboom 33 , Henk Jan Klein Ganseij 33 , Annette D van Dalsen 34 , Annalie Joldersma 34 , Marije Zwakman 34 , Richard P R Groenendijk 35 , Mahsa Montazeri 35 , Stuart Mercer 36 , Benjamin Knight 36 , Gijs van Boxel 36 , Richard J McGregor 37 , Richard J E Skipworth 37 , Cristina Frattini 37 , Alice Bradley 37 , Magnus Nilsson 38 , Masaru Hayami 38 , Biying Huang 38 , James Bundred 39 , Richard Evans 39 , Peter P Grimminger 40 , Pieter C van der Sluis 40 , Uzun Eren 40 , John Saunders 18 , Elena Theophilidou 18 , Zubair Khanzada 18 , Jessie A Elliott 41 , Jeroen Ponten 41 , Sinead King 41 , John V Reynolds 41 , Bruno Sgromo 42 , Khalid Akbari 42 , Samar Shalaby 42 , Christian A Gutschow 43 , Henner Schmidt 43 , Diana Vetter 43 , Krishna Moorthy 44 , Mohamed A H Ibrahim 44 , Grigorious Christodoulidis 44 , Jari V Räsänen 45 , Juha Kauppi 45 , Henna Söderström 45 , Renol Koshy 46 , Dimitrios K Manatakis 47 , Dimitrios P Korkolis 47 , Dimitrios Balalis 47 , Aliki Rompu 47 , Bilal Alkhaffaf 48 , Mohamed Alasmar 48 , Moaad Arebi 48 , Guillaume Piessen 49 , Frederiek Nuytens 49 , Sebastien Degisors 49 , Ahmed Ahmed 50 , Alex Boddy 50 , Suraj Gandhi 50 , Oluwatomini Fashina 50 , Elke Van Daele 51 , Piet Pattyn 51 , William B Robb 52 , Mayilone Arumugasamy 52 , Mohammed Al Azzawi 52 , Jack Whooley 52 , Elif Colak 53 , Engin Aybar 53 , Ahmet C Sari 53 , Mustafa S Uyanik 53 , Ahmet B Ciftci 53 , Raza Sayyed 54 , Bushra Ayub 54 , Ghulam Murtaza 54 , Aniqa Saeed 54 , Priyanka Ramesh 54 , Alexandros Charalabopoulos 55 , Theodore Liakakos 55 , Dimitrios Schizas 55 , Efstratia Baili 55 , Alkistis Kapelouzou 55 , Michele Valmasoni 56 , Elisa Sefora Pierobon 56 , Giovanni Capovilla 56 , Stefano Merigliano 56 , Silviu Constantinoiu 57 , Rodica Birla 57 , Florin Achim 57 , Cristian Gelu Rosianu 57 , Petre Hoara 57 , Raúl Guevara Castro 58 , Andrés Felipe Salcedo 58 , Ionut Negoi 59 , Valentina M Negoita 59 , Cezar Ciubotaru 59 , Bogdan Stoica 59 , Sorin Hostiuc 59 , Nicola Colucci 60 , Stefan P Mönig 60 , Charles-Henri Wassmer 60 , Jeremy Meyer 60 , Flavio Roberto Takeda 61 , Rubens Antonio Aissar Sallum 61 , Ulysses Ribeiro 61 , Ivan Cecconello 61 , Enrique Toledo 62 , Maria Soledad Trugeda 62 , María José Fernández 62 , Carolina Gil 62 , Sonia Castanedo 62 , Arda Isik 63 , Eray Kurnaz 63 , José Flávio Videira 64 , Mariana Peyroteo 64 , Rita Canotilho 64 , Jacopo Weindelmayer 65 , Simone Giacopuzzi 65 , Carlo Alberto De Pasqual 65 , Marcos Bruna 66 , Fernando Mingol 66 , Javier Vaque 66 , Carla Pérez 66 , Alexander W Phillips 67 , Jakub Chmelo 67 , Joshua Brown 67 , Renol Koshy 67 , Laura E Han 67 , James A Gossage 68 , Andrew R Davies 68 , Cara R Baker 68 , Mark Kelly 68 , Mohamed Saad 68 , Daniele Bernardi 69 , Luigi Bonavina 69 , Emanuele Asti 69 , Carlo Riva 69 , Rosa Scaramuzzo 69 , Muhammed Elhadi 70 , Hazem Abdelkarem Ahmed 70 , Ahmed Elhadi 70 , Faruk Ali Elnagar 70 , Ahmed A A Msherghi 70 , Vanessa Wills 71 , Cassidy Campbell 71 , Marisol Perez Cerdeira 71 , Scott Whiting 71 , Neil Merrett 72 , Amitabha Das 72 , Christos Apostolou 72 , Aldenb Lorenzo 72 , Fabiana Sousa 73 , José Adelino Barbosa 73 , Vítor Devezas 73 , Elisabete Barbosa 73 , Cristina Fernandes 73 , Garett Smith 74 , Edward Y Li 74 , Nazim Bhimani 74 , Priscilla Chan 74 , Krishna Kotecha 74 , Michael W Hii 75 , Salena M Ward 75 , MaryAnn Johnson 75 , Matthew Read 75 , Lynn Chong 75 , Michael J Hollands 76 , Matthew Allaway 76 , Arthur Richardson 76 , Emma Johnston 76 , Andy Z L Chen 76 , Harsh Kanhere 77 , Shalvin Prasad 77 , Patrick McQuillan 77 , Tim Surman 77 , MarkusI Trochsler 78 , W A Schofield 78 , Syeda Khadijah Ahmed 78 , Jessica L Reid 78 , Mark C Harris 78 , Sivakumar Gananadha 79 , Jessica Farrant 79 , Nicole Rodrigues 79 , James Fergusson 79 , Andrew Hindmarsh 80 , Zeeshan Afzal 80 , Peter Safranek 80 , Vijay Sujendran 80 , Siobhan Rooney 80 , Carlos Loureiro 81 , Saioa Leturio Fernández 81 , Ismael Díez Del Val 81 , Shameen Jaunoo 82 , Lauren Kennedy 82 , Ahmed Hussain 82 , Dimitrios Theodorou 83 , Tania Triantafyllou 83 , Charalampos Theodoropoulos 83 , Theodora Palyvou 83 , Muhammed Elhadi 84 , Fatima Abdullah Ben Taher 84 , Mustafa Ekheel 84 , Ahmed A A Msherghi 84
Affiliations
- 1 Department of Surgery, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Sander.Ubels@radboudumc.nl.
- 2 Department of Surgery, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Surgery, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands.
- 3 Department of Surgery, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
- 4 Department of Surgery, Maastricht University Medical Center+, Maastricht, the Netherlands.
- 5 Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands.
- 6 Department of Surgery, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
- 7 Department of Surgery, Reinier de Graaf Gasthuis, Delft, the Netherlands.
- 8 Department of Surgery, ZGT Hospital Group, Almelo, the Netherlands.
- 9 Department of Upper Gastrointestinal Surgery, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
- 10 Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
- 11 Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands.
- 12 Department of Gastroenterology and Hepatology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
- 13 Department of Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands.
- 14 Department of Operating Rooms, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
- 15 Elisabeth-Tweesteden Ziekenhuis, Tilburg, the Netherlands.
- 16 Canisius-Wilhelmina Ziekenhuis, Nijmegen, the Netherlands.
- 17 Radboud University Medical Center, Nijmegen, the Netherlands.
- 18 Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
- 19 Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, the Netherlands.
- 20 AmsterdamUMC, Location VUmc, Amsterdam, the Netherlands.
- 21 University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
- 22 Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands.
- 23 Erasmus Medical Center, Rotterdam, the Netherlands.
- 24 Ziekenhuisgroep Twente, Almelo, the Netherlands.
- 25 Zuyderland Medisch Centrum, Heerlen, the Netherlands.
- 26 Martini Ziekenhuis, Groningen, the Netherlands.
- 27 Leiden University Medical Center, Leiden, the Netherlands.
- 28 Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, the Netherlands.
- 29 Spaarne Gasthuis, Haarlem, the Netherlands.
- 30 St. Antonius Ziekenhuis, Nieuwegein, the Netherlands.
- 31 Albert Schweitzer, Dordrecht, the Netherlands.
- 32 Gelre, Apeldoorn, the Netherlands.
- 33 Medisch Spectrum Twente, Enschede, the Netherlands.
- 34 Isala, Zwolle, the Netherlands.
- 35 IJsselland Ziekenhuis, Cappelle aan de Ijssel, the Netherlands.
- 36 Portsmouth Hospital University Trust, Portsmouth, United Kingdom.
- 37 University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.
- 38 Karolinska University Hospital, Stockholm, Sweden.
- 39 Queen Elizabeth Hospital, Birmingham, United Kingdom.
- 40 University Medical Center Mainz, Mainz, Germany.
- 41 Trinity St. James's Cancer Institute, Dublin, Ireland.
- 42 Churchill Hospital, Oxford University Hospitals, Oxford, United Kingdom.
- 43 University Hospital Zurich, Zurich, Switzerland.
- 44 Imperial, London, United Kingdom.
- 45 Helsinki University Hospital, Helsinki University, Helsinki, Finland.
- 46 Conventry and Warwickshire, Conventry, United Kingdom.
- 47 Saint Savvas Cancer Hospital, Athens, Greece.
- 48 Salford Royal NHS Foundation Trust, Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom.
- 49 University Lille, Claude Huriez University Hospital, CHU de Lille, Lille, France.
- 50 University of Leicester, Leicester, United Kingdom.
- 51 Ghent University Hospital, Ghent, Belgium.
- 52 Beaumont Hospital, Dublin, Ireland.
- 53 Samsun Training and Research Hospital, Samsun, Turkey.
- 54 Patel Hospital, Karachi, Pakistan.
- 55 Laiko General Hospital, Athens, Greece.
- 56 University Hospital of Padova, Padova, Italy.
- 57 Sf. Maria Hospital, Bucharest, Romania.
- 58 Clinica Universitaria Colombia, Bogota, Colombia.
- 59 Carol Davila University of Medicine and Pharmacy Bucharest, Emergency Hospital of Bucharest, Bucharest, Romania.
- 60 Geneva University Hospitals, Geneva, Switzerland.
- 61 University of Sao Paulo, Sao Paulo, Brazil.
- 62 Valdecilla Hospital, Santander, Spain.
- 63 Erzincan Binali Yildirim University, Erzincan, Turkey.
- 64 Instituto Português de Oncologica, Porto, Portugal.
- 65 Verona University Hospital, Verona, Italy.
- 66 La Fe Hospital, Valencia, Spain.
- 67 Royal Victoria Infirmary, Newcastle Upon Tyne, United Kingdom.
- 68 Guy's and St Thomas' Hospitals, London, United Kingdom.
- 69 University of Milan, Milan, Italy.
- 70 Tripoli University Hospital, Tripoli, Libya.
- 71 John Hunter New England LHD, Newcastle, Australia.
- 72 South Western Sydney Local Health District, Sydney, Australia.
- 73 Centro Hospitalar Universitário São João, Oporto, Portugal.
- 74 Royal North Shore Hospital, Sydney, Australia.
- 75 St Vincent's Hospital, Melbourne, Australia.
- 76 Westmead Hospital Hospital, Sydney, Australia.
- 77 Royal Adelaide Hospital, Adelaide, Australia.
- 78 The Queen Elizabeth Hospital, Adelaide, Australia.
- 79 Canberra Hospital, Canberra, Australia.
- 80 Addenbrooke's Hospital, Cambridge, United Kingdom.
- 81 University Hospital Basurto, Bilbao, Spain.
- 82 Brighton & Sussex University Hospitals, Brighton, United Kingdom.
- 83 Hippocration Hospital, Athens, Greece.
- 84 Sabratha National Cancer Institute, Sabratha, Libya.
- PMID: 36732207
- DOI: 10.1016/j.ejso.2023.01.010
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Multicenter Study
Practice variation in anastomotic leak after esophagectomy: Unravelling differences in failure to rescue
Sander Ubels et al.
Eur J Surg Oncol.
2023 May.
Free article
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doi: 10.1016/j.ejso.2023.01.010.
Epub 2023 Jan 20.
Authors
Sander Ubels
1
, Eric Matthée
2
, Moniek Verstegen
3
, Bastiaan Klarenbeek
3
, Stefan Bouwense
4
, Mark I van Berge Henegouwen
5
, Freek Daams
6
, Jan Willem T Dekker
7
, Marc J van Det
8
, Stijn van Esser
7
, Ewen A Griffiths
9
, Jan Willem Haveman
10
, Grard Nieuwenhuijzen
11
, Peter D Siersema
12
, Bas Wijnhoven
13
, Gerjon Hannink
14
, Frans van Workum
2
, Camiel Rosman
3
; TENTACLE – Esophagus collaborative group; Writing Committee; Joos Heisterkamp
15
, Fatih Polat
16
, Jeroen Schouten
17
, Pritam Singh
18
; Study collaborators
Collaborators
-
Cettela A M Slootmans 17 , Gijs Ultee 17 , Suzanne S Gisbertz 19 , Wietse J Eshuis 19 , Marianne C Kalff 19 , Minke L Feenstra 19 , Donald L van der Peet 20 , Wessel T Stam 20 , Boudewijn Van Etten 21 , Floris Poelmann 21 , Nienke Vuurberg 21 , Jan Willem van den Berg 21 , Ingrid S Martijnse 15 , Robert M Matthijsen 15 , Misha Luyer 22 , Wout Curvers 22 , Tom Nieuwenhuijzen 22 , Annick E Taselaar 23 , Ewout A Kouwenhoven 24 , Merel Lubbers 24 , Meindert Sosef 25 , Frederik Lecot 25 , Tessa C M Geraedts 25 , Frits van den Wildenberg 16 , Wendy Kelder 26 , Merel Lubbers 26 , Peter C Baas 26 , Job W A de Haas 26 , Henk H Hartgrink 27 , Renu R Bahadoer 27 , Johanna W van Sandick 28 , Koen J Hartemink 28 , Xander Veenhof 28 , Hein Stockmann 29 , Burak Gorgec 29 , Pepijn Weeder 29 , Marinus J Wiezer 30 , Charlotte M S Genders 30 , Eric Belt 31 , Bjorn Blomberg 31 , Peter van Duijvendijk 32 , Linda Claassen 32 , David Reetz 32 , Pascal Steenvoorde 33 , Walter Mastboom 33 , Henk Jan Klein Ganseij 33 , Annette D van Dalsen 34 , Annalie Joldersma 34 , Marije Zwakman 34 , Richard P R Groenendijk 35 , Mahsa Montazeri 35 , Stuart Mercer 36 , Benjamin Knight 36 , Gijs van Boxel 36 , Richard J McGregor 37 , Richard J E Skipworth 37 , Cristina Frattini 37 , Alice Bradley 37 , Magnus Nilsson 38 , Masaru Hayami 38 , Biying Huang 38 , James Bundred 39 , Richard Evans 39 , Peter P Grimminger 40 , Pieter C van der Sluis 40 , Uzun Eren 40 , John Saunders 18 , Elena Theophilidou 18 , Zubair Khanzada 18 , Jessie A Elliott 41 , Jeroen Ponten 41 , Sinead King 41 , John V Reynolds 41 , Bruno Sgromo 42 , Khalid Akbari 42 , Samar Shalaby 42 , Christian A Gutschow 43 , Henner Schmidt 43 , Diana Vetter 43 , Krishna Moorthy 44 , Mohamed A H Ibrahim 44 , Grigorious Christodoulidis 44 , Jari V Räsänen 45 , Juha Kauppi 45 , Henna Söderström 45 , Renol Koshy 46 , Dimitrios K Manatakis 47 , Dimitrios P Korkolis 47 , Dimitrios Balalis 47 , Aliki Rompu 47 , Bilal Alkhaffaf 48 , Mohamed Alasmar 48 , Moaad Arebi 48 , Guillaume Piessen 49 , Frederiek Nuytens 49 , Sebastien Degisors 49 , Ahmed Ahmed 50 , Alex Boddy 50 , Suraj Gandhi 50 , Oluwatomini Fashina 50 , Elke Van Daele 51 , Piet Pattyn 51 , William B Robb 52 , Mayilone Arumugasamy 52 , Mohammed Al Azzawi 52 , Jack Whooley 52 , Elif Colak 53 , Engin Aybar 53 , Ahmet C Sari 53 , Mustafa S Uyanik 53 , Ahmet B Ciftci 53 , Raza Sayyed 54 , Bushra Ayub 54 , Ghulam Murtaza 54 , Aniqa Saeed 54 , Priyanka Ramesh 54 , Alexandros Charalabopoulos 55 , Theodore Liakakos 55 , Dimitrios Schizas 55 , Efstratia Baili 55 , Alkistis Kapelouzou 55 , Michele Valmasoni 56 , Elisa Sefora Pierobon 56 , Giovanni Capovilla 56 , Stefano Merigliano 56 , Silviu Constantinoiu 57 , Rodica Birla 57 , Florin Achim 57 , Cristian Gelu Rosianu 57 , Petre Hoara 57 , Raúl Guevara Castro 58 , Andrés Felipe Salcedo 58 , Ionut Negoi 59 , Valentina M Negoita 59 , Cezar Ciubotaru 59 , Bogdan Stoica 59 , Sorin Hostiuc 59 , Nicola Colucci 60 , Stefan P Mönig 60 , Charles-Henri Wassmer 60 , Jeremy Meyer 60 , Flavio Roberto Takeda 61 , Rubens Antonio Aissar Sallum 61 , Ulysses Ribeiro 61 , Ivan Cecconello 61 , Enrique Toledo 62 , Maria Soledad Trugeda 62 , María José Fernández 62 , Carolina Gil 62 , Sonia Castanedo 62 , Arda Isik 63 , Eray Kurnaz 63 , José Flávio Videira 64 , Mariana Peyroteo 64 , Rita Canotilho 64 , Jacopo Weindelmayer 65 , Simone Giacopuzzi 65 , Carlo Alberto De Pasqual 65 , Marcos Bruna 66 , Fernando Mingol 66 , Javier Vaque 66 , Carla Pérez 66 , Alexander W Phillips 67 , Jakub Chmelo 67 , Joshua Brown 67 , Renol Koshy 67 , Laura E Han 67 , James A Gossage 68 , Andrew R Davies 68 , Cara R Baker 68 , Mark Kelly 68 , Mohamed Saad 68 , Daniele Bernardi 69 , Luigi Bonavina 69 , Emanuele Asti 69 , Carlo Riva 69 , Rosa Scaramuzzo 69 , Muhammed Elhadi 70 , Hazem Abdelkarem Ahmed 70 , Ahmed Elhadi 70 , Faruk Ali Elnagar 70 , Ahmed A A Msherghi 70 , Vanessa Wills 71 , Cassidy Campbell 71 , Marisol Perez Cerdeira 71 , Scott Whiting 71 , Neil Merrett 72 , Amitabha Das 72 , Christos Apostolou 72 , Aldenb Lorenzo 72 , Fabiana Sousa 73 , José Adelino Barbosa 73 , Vítor Devezas 73 , Elisabete Barbosa 73 , Cristina Fernandes 73 , Garett Smith 74 , Edward Y Li 74 , Nazim Bhimani 74 , Priscilla Chan 74 , Krishna Kotecha 74 , Michael W Hii 75 , Salena M Ward 75 , MaryAnn Johnson 75 , Matthew Read 75 , Lynn Chong 75 , Michael J Hollands 76 , Matthew Allaway 76 , Arthur Richardson 76 , Emma Johnston 76 , Andy Z L Chen 76 , Harsh Kanhere 77 , Shalvin Prasad 77 , Patrick McQuillan 77 , Tim Surman 77 , MarkusI Trochsler 78 , W A Schofield 78 , Syeda Khadijah Ahmed 78 , Jessica L Reid 78 , Mark C Harris 78 , Sivakumar Gananadha 79 , Jessica Farrant 79 , Nicole Rodrigues 79 , James Fergusson 79 , Andrew Hindmarsh 80 , Zeeshan Afzal 80 , Peter Safranek 80 , Vijay Sujendran 80 , Siobhan Rooney 80 , Carlos Loureiro 81 , Saioa Leturio Fernández 81 , Ismael Díez Del Val 81 , Shameen Jaunoo 82 , Lauren Kennedy 82 , Ahmed Hussain 82 , Dimitrios Theodorou 83 , Tania Triantafyllou 83 , Charalampos Theodoropoulos 83 , Theodora Palyvou 83 , Muhammed Elhadi 84 , Fatima Abdullah Ben Taher 84 , Mustafa Ekheel 84 , Ahmed A A Msherghi 84
Affiliations
- 1 Department of Surgery, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Sander.Ubels@radboudumc.nl.
- 2 Department of Surgery, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Surgery, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands.
- 3 Department of Surgery, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
- 4 Department of Surgery, Maastricht University Medical Center+, Maastricht, the Netherlands.
- 5 Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands.
- 6 Department of Surgery, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
- 7 Department of Surgery, Reinier de Graaf Gasthuis, Delft, the Netherlands.
- 8 Department of Surgery, ZGT Hospital Group, Almelo, the Netherlands.
- 9 Department of Upper Gastrointestinal Surgery, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
- 10 Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
- 11 Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands.
- 12 Department of Gastroenterology and Hepatology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
- 13 Department of Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands.
- 14 Department of Operating Rooms, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
- 15 Elisabeth-Tweesteden Ziekenhuis, Tilburg, the Netherlands.
- 16 Canisius-Wilhelmina Ziekenhuis, Nijmegen, the Netherlands.
- 17 Radboud University Medical Center, Nijmegen, the Netherlands.
- 18 Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
- 19 Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, the Netherlands.
- 20 AmsterdamUMC, Location VUmc, Amsterdam, the Netherlands.
- 21 University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
- 22 Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands.
- 23 Erasmus Medical Center, Rotterdam, the Netherlands.
- 24 Ziekenhuisgroep Twente, Almelo, the Netherlands.
- 25 Zuyderland Medisch Centrum, Heerlen, the Netherlands.
- 26 Martini Ziekenhuis, Groningen, the Netherlands.
- 27 Leiden University Medical Center, Leiden, the Netherlands.
- 28 Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, the Netherlands.
- 29 Spaarne Gasthuis, Haarlem, the Netherlands.
- 30 St. Antonius Ziekenhuis, Nieuwegein, the Netherlands.
- 31 Albert Schweitzer, Dordrecht, the Netherlands.
- 32 Gelre, Apeldoorn, the Netherlands.
- 33 Medisch Spectrum Twente, Enschede, the Netherlands.
- 34 Isala, Zwolle, the Netherlands.
- 35 IJsselland Ziekenhuis, Cappelle aan de Ijssel, the Netherlands.
- 36 Portsmouth Hospital University Trust, Portsmouth, United Kingdom.
- 37 University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.
- 38 Karolinska University Hospital, Stockholm, Sweden.
- 39 Queen Elizabeth Hospital, Birmingham, United Kingdom.
- 40 University Medical Center Mainz, Mainz, Germany.
- 41 Trinity St. James's Cancer Institute, Dublin, Ireland.
- 42 Churchill Hospital, Oxford University Hospitals, Oxford, United Kingdom.
- 43 University Hospital Zurich, Zurich, Switzerland.
- 44 Imperial, London, United Kingdom.
- 45 Helsinki University Hospital, Helsinki University, Helsinki, Finland.
- 46 Conventry and Warwickshire, Conventry, United Kingdom.
- 47 Saint Savvas Cancer Hospital, Athens, Greece.
- 48 Salford Royal NHS Foundation Trust, Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom.
- 49 University Lille, Claude Huriez University Hospital, CHU de Lille, Lille, France.
- 50 University of Leicester, Leicester, United Kingdom.
- 51 Ghent University Hospital, Ghent, Belgium.
- 52 Beaumont Hospital, Dublin, Ireland.
- 53 Samsun Training and Research Hospital, Samsun, Turkey.
- 54 Patel Hospital, Karachi, Pakistan.
- 55 Laiko General Hospital, Athens, Greece.
- 56 University Hospital of Padova, Padova, Italy.
- 57 Sf. Maria Hospital, Bucharest, Romania.
- 58 Clinica Universitaria Colombia, Bogota, Colombia.
- 59 Carol Davila University of Medicine and Pharmacy Bucharest, Emergency Hospital of Bucharest, Bucharest, Romania.
- 60 Geneva University Hospitals, Geneva, Switzerland.
- 61 University of Sao Paulo, Sao Paulo, Brazil.
- 62 Valdecilla Hospital, Santander, Spain.
- 63 Erzincan Binali Yildirim University, Erzincan, Turkey.
- 64 Instituto Português de Oncologica, Porto, Portugal.
- 65 Verona University Hospital, Verona, Italy.
- 66 La Fe Hospital, Valencia, Spain.
- 67 Royal Victoria Infirmary, Newcastle Upon Tyne, United Kingdom.
- 68 Guy's and St Thomas' Hospitals, London, United Kingdom.
- 69 University of Milan, Milan, Italy.
- 70 Tripoli University Hospital, Tripoli, Libya.
- 71 John Hunter New England LHD, Newcastle, Australia.
- 72 South Western Sydney Local Health District, Sydney, Australia.
- 73 Centro Hospitalar Universitário São João, Oporto, Portugal.
- 74 Royal North Shore Hospital, Sydney, Australia.
- 75 St Vincent's Hospital, Melbourne, Australia.
- 76 Westmead Hospital Hospital, Sydney, Australia.
- 77 Royal Adelaide Hospital, Adelaide, Australia.
- 78 The Queen Elizabeth Hospital, Adelaide, Australia.
- 79 Canberra Hospital, Canberra, Australia.
- 80 Addenbrooke's Hospital, Cambridge, United Kingdom.
- 81 University Hospital Basurto, Bilbao, Spain.
- 82 Brighton & Sussex University Hospitals, Brighton, United Kingdom.
- 83 Hippocration Hospital, Athens, Greece.
- 84 Sabratha National Cancer Institute, Sabratha, Libya.
- PMID: 36732207
- DOI: 10.1016/j.ejso.2023.01.010
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Erratum to "Practice variation in anastomotic leak after esophagectomy: Unravelling differences in failure to rescue" [Eur J Surg Oncol 49 (5) (May 2023) 974-982].Ubels S, Matthée E, Verstegen M, Klarenbeek B, Bouwense S, van Berge Henegouwen MI, Daams F, Dekker JWT, van Det MJ, van Esser S, Griffiths EA, Haveman JW, Nieuwenhuijzen G, Siersema PD, Wijnhoven B, Hannink G, van Workum F, Rosman C; TENTACLE – Esophagus collaborative group. Ubels S, et al. Eur J Surg Oncol. 2023 Sep;49(9):106993. doi: 10.1016/j.ejso.2023.106993. Epub 2023 Aug 10. Eur J Surg Oncol. 2023. PMID: 37572559 No abstract available.
Abstract
Introduction: Failure to rescue (FTR) is an important outcome measure after esophagectomy and reflects mortality after postoperative complications. Differences in FTR have been associated with hospital resection volume. However, insight into how centers manage complications and achieve their outcomes is lacking. Anastomotic leak (AL) is a main contributor to FTR. This study aimed to assess differences in FTR after AL between centers, and to identify factors that explain these differences.
Methods: TENTACLE - Esophagus is a multicenter, retrospective cohort study, which included 1509 patients with AL after esophagectomy. Differences in FTR were assessed between low-volume (<20 resections), middle-volume (20-60 resections) and high-volume centers (≥60 resections). Mediation analysis was performed using logistic regression, including possible mediators for FTR: case-mix, hospital resources, leak severity and treatment.
Results: FTR after AL was 11.7%. After adjustment for confounders, FTR was lower in high-volume vs. low-volume (OR 0.44, 95%CI 0.2-0.8), but not versus middle-volume centers (OR 0.67, 95%CI 0.5-1.0). After mediation analysis, differences in FTR were found to be explained by lower leak severity, lower secondary ICU readmission rate and higher availability of therapeutic modalities in high-volume centers. No statistically significant direct effect of hospital volume was found: high-volume vs. low-volume 0.86 (95%CI 0.4-1.7), high-volume vs. middle-volume OR 0.86 (95%CI 0.5-1.4).
Conclusion: Lower FTR in high-volume compared with low-volume centers was explained by lower leak severity, less secondary ICU readmissions and higher availability of therapeutic modalities. To reduce FTR after AL, future studies should investigate effective strategies to reduce leak severity and prevent secondary ICU readmission.
Keywords: Anastomotic leak; Complications; Esophagectomy; Failure to rescue; Practice variation.
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Conflict of interest statement
Declaration of competing interest All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare funding by Medtronic for the submitted work. PS reports grants from The Enose Company, grants and other from Motus GI, grants from Pentax, grants from Micro-Tech, other from Boston Scientific outside the submitted work; BK reports grants from Medtronic, grants from ZonMw, outside the submitted work; MIvBH reports other from Mylan, other from Alesi Surgical, other from Johnson and Johnson, other from BBraun, other from Medtronic, grants from Olympus, grants from Stryker, outside the submitted work; all fees unrelated to submitted work, paid to institution.
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