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Comment
. 2023 Feb;55(2):176-177.
doi: 10.1038/s41588-023-01304-2.

Mutational signatures in human small intestinal crypts indicate APOBEC mutagenesis

No authors listed
Comment

Mutational signatures in human small intestinal crypts indicate APOBEC mutagenesis

No authors listed. Nat Genet. 2023 Feb.
No abstract available

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Comment on

  • APOBEC mutagenesis is a common process in normal human small intestine.
    Wang Y, Robinson PS, Coorens THH, Moore L, Lee-Six H, Noorani A, Sanders MA, Jung H, Katainen R, Heuschkel R, Brunton-Sim R, Weston R, Read D, Nobbs B, Fitzgerald RC, Saeb-Parsy K, Martincorena I, Campbell PJ, Rushbrook S, Zilbauer M, Buczacki SJA, Stratton MR. Wang Y, et al. Nat Genet. 2023 Feb;55(2):246-254. doi: 10.1038/s41588-022-01296-5. Epub 2023 Jan 26. Nat Genet. 2023. PMID: 36702998 Free PMC article.

References

    1. Alexandrov, L. B. et al. The repertoire of mutational signatures in human cancer. Nature 578, 94–101 (2020). This paper summarizes mutational signatures in human cancer and the mutational burden that they contribute. - DOI - PubMed - PMC
    1. Moore, L. et al. The mutational landscape of human somatic and germline cells. Nature 597, 381–386 (2021). This paper presents mutational signatures in multiple human tissues. - DOI - PubMed
    1. Petljak, M. & Maciejowski, J. Molecular origins of APOBEC-associated mutations in cancer. DNA Repair 94, 102905 (2020). A review article that summarizes available evidence around the APOBEC deaminases that are responsible for cancer mutagenesis. - DOI - PubMed - PMC
    1. Nik-Zainal, S. et al. Mutational processes molding the genomes of 21 breast cancers. Cell 149, 979–993 (2012). This paper proposes the activity of specific members of the APOBEC family of cytidine deaminases as possible cause for APOBEC mutational signatures in cancers.
    1. Teng, B., Burant, C. F. & Davidson, N. O. Molecular cloning of an apolipoprotein B messenger RNA editing protein. Science 260, 1816–1819 (1993). This paper identifies APOBEC1 and establishes its role as the mRNA-editing enzyme for apolipoprotein B, a crucial component of lipoproteins that are responsible for carrying lipids. - DOI - PubMed

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