Master kinases extracted from proteogenomic networks in glioblastoma drive cancer subtypes
- PMID: 36732637
- DOI: 10.1038/s43018-022-00511-w
Master kinases extracted from proteogenomic networks in glioblastoma drive cancer subtypes
Comment on
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Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy.Nat Cancer. 2023 Feb;4(2):181-202. doi: 10.1038/s43018-022-00510-x. Epub 2023 Feb 2. Nat Cancer. 2023. PMID: 36732634 Free PMC article.
References
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- Varn, F. S. et al. Glioma progression is shaped by genetic evolution and microenvironment interactions. Cell 185, 2184–2199 (2022). This paper reports the transcriptomic results of temporally separated pairs of IDH-mutant and IDH-wild-type gliomas from the Glioma Longitudinal AnalySiS (GLASS) consortium. - DOI - PubMed
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- Carro, M. S. et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 463, 318–325 (2010). This paper reports the unbiased interrogation of glioma-specific regulatory networks and the experimental validation of two master regulators of the mesenchymal phenotype of malignant glioma. - DOI - PubMed
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