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Editorial
. 2023 Jan 17:16:1136930.
doi: 10.3389/fnmol.2023.1136930. eCollection 2023.

Editorial: Factors contributing to dopaminergic cell death

Sandra Blaess  1 , Antonio J Herrera  2   3
Affiliations
Editorial

Editorial: Factors contributing to dopaminergic cell death

Sandra Blaess et al. Front Mol Neurosci. .
No abstract available

Keywords: damaging factors; dopaminergic cell death; early detection; neuroprotection; new treatments.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Molecular and cellular damage that can lead to degeneration of SNc-DA neurons during the course of human life. Years of life: the progression of color in the bar represents the loss of functionality associated with the cellular aging process. Below this bar, some of the processes identified as harmful to DA neurons of the SNc (and other neurons) are summarized. These include processes initiated and maintained by genetic and non-genetic factors interacting in complex and hidden ways long before the first symptoms of the disease appear; the end result is the death of these neurons. Unfortunately, when motor symptoms appear—the first unmistakable signs of PD (vertical red line)—neuronal damage is extensive and irreversible. If we are to move beyond the temporary palliative maintenance of dopaminergic signaling that characterizes current treatments, we must identify the asymptomatic death of neurons early, discover the exact mechanisms that cause their death, and then use treatments that can prevent and/or stop neurodegeneration in the prodromal/asymptomatic stages of the disease. This Frontiers Research Topic includes a number of studies addressing either the molecular mechanisms of neurodegeneration (green box) or potential treatment options (pink box).
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