Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials

Sophie Thomas^{1

2}, Leanne Embry³, Karin Walsh^{4

5}, Kim Bull⁶, Richard Grundy^{1

2}, Colin Kennedy⁶, Jurgen Lemiere⁷, Pablo Hernáiz Driever⁸, Jennifer Limond⁹, Mathilde Chevignard^{10

11

12}, Kristina Hardy^{4

5}

Affiliations

¹ Department of Paediatric Neuropsychology, Nottingham Children's Hospital, Queen's Medical Centre, Nottingham, UK.
² Child Brain Tumour Research Centre, School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
³ Pediatric Hematology/Oncology, UT Health, San Antonio, Texas, USA.
⁴ Division of Pediatric Neuropsychology, Children's National Hospital, Washington, DC, USA.
⁵ Departments of Psychiatry & Behavioral Medicine and Pediatrics, The George Washington University School of Medicine, Washington, DC, USA.
⁶ Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, UK.
⁷ Department Oncology, Pediatric Hemato-Oncology, KULeuven, University Hospital Leuven, Leuven, Belgium.
⁸ Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
⁹ Department of Psychology, University of Exeter, Exeter, UK.
¹⁰ Rehabilitation Department for Children with Acquired Neurological Injury; and Outreach Team for Children and Adolescents with Acquired Brain Injury, Saint Maurice Hospitals, Saint Maurice, France.
¹¹ Laboratoire d'Imagerie Biomédicale, LIB, Sorbonne Université, Paris, France.
¹² GRC24, Handicap Moteur et Cognitif et Réadaptation (HaMCRe), Sorbonne Université, Paris, France.

PMID: 36734371
DOI: 10.1002/pbc.30171

Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials

Sophie Thomas et al. Pediatr Blood Cancer. 2023 May.

. 2023 May;70(5):e30171.

doi: 10.1002/pbc.30171. Epub 2023 Feb 3.

Authors

Affiliations

¹ Department of Paediatric Neuropsychology, Nottingham Children's Hospital, Queen's Medical Centre, Nottingham, UK.
² Child Brain Tumour Research Centre, School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
³ Pediatric Hematology/Oncology, UT Health, San Antonio, Texas, USA.
⁴ Division of Pediatric Neuropsychology, Children's National Hospital, Washington, DC, USA.
⁵ Departments of Psychiatry & Behavioral Medicine and Pediatrics, The George Washington University School of Medicine, Washington, DC, USA.
⁶ Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, UK.
⁷ Department Oncology, Pediatric Hemato-Oncology, KULeuven, University Hospital Leuven, Leuven, Belgium.
⁸ Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
⁹ Department of Psychology, University of Exeter, Exeter, UK.
¹⁰ Rehabilitation Department for Children with Acquired Neurological Injury; and Outreach Team for Children and Adolescents with Acquired Brain Injury, Saint Maurice Hospitals, Saint Maurice, France.
¹¹ Laboratoire d'Imagerie Biomédicale, LIB, Sorbonne Université, Paris, France.
¹² GRC24, Handicap Moteur et Cognitif et Réadaptation (HaMCRe), Sorbonne Université, Paris, France.

PMID: 36734371
DOI: 10.1002/pbc.30171

Abstract

The importance of measuring quality of survival within paediatric oncology trials is increasingly recognised. However, capturing neuropsychological outcomes and other aspects of quality of survival in the context of large or multinational trials can be challenging. We provide examples of protocols designed to address this challenge recently employed in clinical trials in the USA and Europe. We discuss their respective strengths and challenges, obstacles encountered and future opportunities for transatlantic collaboration.

Keywords: brain tumour; cancer; child; cognitive; late effects; paediatric; quality of survival.

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References

REFERENCES

1. Treadgold B, Kennedy C, Spoudeas H, Sugden E, Walker D, Bull K. Paediatric neuro-oncology rehabilitation in the UK: carer and provider perspectives. BMJ Paediatr Open. 2019;3(1):e000567.
1. Hewitt CE, Kumaravel B, Dumville JC, Torgerson DJ. Assessing the impact of attrition in randomized controlled trials. J Clin Epidemiol. 2010;63(11):1264-1270. Trial attrition study group.
1. Embry L, Annett RD, Kunin-Batson A, et al. Implementation of multi-site neurocognitive assessments within a pediatric cooperative group: can it be done. Pediatr Blood Cancer. 2012;59(3):536-539.
1. Limond JA, Bull KS, Calaminus G, Kennedy CR, Spoudeas HA, Chevignard MP. Quality of survival assessment in European childhood brain tumour trials, for children aged 5 years and over. Eur J Paediatr Neurol. 2015;19(2):202-210.
1. Limond J, Thomas S, Bull KS, et al. Quality of survival assessment in European childhood brain tumour trials, for children below the age of 5 years. Eur J Paediatr Neurol. 2020:25.

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Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials

Affiliations

Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials

Authors

Affiliations

Abstract

References

REFERENCES

MeSH terms

LinkOut - more resources

Full Text Sources

Medical