Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Mar;5(2):e220183.
doi: 10.1148/rycan.220183.

Pretherapy Ferumoxytol-enhanced MRI for Metastatic Breast Cancer: A New Approach for Predicting Tumor Delivery of Macromolecular Therapeutics?

Heike E Daldrup-Link  1
Affiliations
Comment

Pretherapy Ferumoxytol-enhanced MRI for Metastatic Breast Cancer: A New Approach for Predicting Tumor Delivery of Macromolecular Therapeutics?

Heike E Daldrup-Link. Radiol Imaging Cancer. 2023 Mar.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Disclosures of conflicts of interest: H.E.D.L. NIH/NCI R01CA269231, NIH/NIAMS 5R01AR054458-11, NIH/NICHD R01HD103638, NIH/NCI UG3CA268112, NIH/NIAMS R21AR075863, NIH/NICHD R21HD101129, NIH/NCI U24CA264298, NIH/NCI 5P30CA124435-10, Cancer Research Institute Technology Impact Award, Sarcoma Foundation of America, R24OD019813-01 NIH Office of the Director, The ReMission Alliance Against Brain Tumors, MegaPro, R01CA263500 NIH/NCI (PI C. Mackall), Stanford Center for Artificial Intelligence in Medicine and Imaging (AIMI); Patents planned, issued, or pending: Shames, D.M.; Brasch, R.C.; Daldrup, H.E.: Imaging method for determining the pathologic grade of a tumor in situ, useful for determining malignancy or non-malignancy Patent: US6009342 Patent Assignee: University of California; Daldrup-Link, H.: Immunotherapy for cancer treatment using iron oxide nanoparticles Patent: US20130344003 Patent Assignee: Stanford University; Daldrup-Link, H.: In vivo iron labeling of stem cells and tracking these labeled stem cells after their transplantation Patent: US9579349, issued 2/28/17 Patent Assignee: Stanford University; Nejadnik H., Lenkov O., Daldrup-Link, H.: Compositions and methods for mesenchymal and/or chondrogenic differentiation of stem cells Patent: US20140271616 A Patent Assignee: Stanford University; Falconer R., Loadman P., Gill J.; Rao, J.; Daldrup H.E.: Activatable theranostic nanoparticles Patent: WO 2015014756. Patent Assignee: Bradford University, UK and Stanford University, USA; Li K., Nejadnik H., Daldrup-Link, H.: Dual-modality Imaging Probe for Combined Localization and Apoptosis Detection of Stem Cells Patent: US20180036435 Patent Assignee: Stanford University; Daldrup-Link, H., Mohanty S.: AntiWarburg Nanoparticles Patent: WO/2018/217943 Patent Assignee: Stanford University; Participation on a data safety monitoring board or advisory board: Advisory board member, Stanford Cancer Imaging T32 Training Program; Associate Chair for Diversity, Department of Radiology, Stanford School of Medicine; Co-Program Director, Mentoring to AdVance womEN in Science (MAVENS) program, Stanford School of Medicine; Board Member, SPR Research Foundation, Society for Pediatric Radiology (SPR); Advisory committee member, Justice Diversity, Equity and Inclusion (JEDI) at the Stanford Cancer Institute (SCI); Leadership or fiduciary role in other board, society, committee or advocacy group, paid or unpaid: Co-Chair, Steering Committee, The NIH Common Fund’s Cellular Senescence Network (SenNet) Program: https://commonfund.nih.gov/senescence; Ad hoc reviewer, Nanotechnology (Nano) Study Section. NIH CSR (Center for Scientific Review); Ad Hoc Reviewer, ZRG1 SBIB-Q 03 Study Section; Biomedical Imaging & Bioengineering, Center for Scientific Reviews; Reviewer for research grant applications for Emerson Collective Cancer Research Fund; Reviewer for research grant applications for the Swiss Cancer Research Foundation; Reviewer for the Florida Department of Health’s Biomedical Research Program; Reviewer for the Belgian Foundation Against Cancer; receipt of equipment, materials, drugs or other services from MegaPro Biomedical Co Ltd; Managing Director of Monasteria Press; associate editor of Radiology: Imaging Cancer.

Figures

Heike Elisabeth Daldrup-Link, MD, PhD, is a tenured professor of radiology, co-director of the Cancer Imaging Program, and associate chair for diversity in the department of radiology at Stanford University. Dr Daldrup-Link has published over 170 peer-reviewed research articles, 87 review articles, editorials, and book chapters, eight books, and seven patents. Dr Daldrup-Link is an elected member of the American Society for Clinical Investigation (honor society for clinician-scientists), fellow-elect of the World Molecular Imaging Society, and fellow-elect of the American Institute of Medical and Biological Engineering.
Heike Elisabeth Daldrup-Link, MD, PhD, is a tenured professor of radiology, co-director of the Cancer Imaging Program, and associate chair for diversity in the department of radiology at Stanford University. Dr Daldrup-Link has published over 170 peer-reviewed research articles, 87 review articles, editorials, and book chapters, eight books, and seven patents. Dr Daldrup-Link is an elected member of the American Society for Clinical Investigation (honor society for clinician-scientists), fellow-elect of the World Molecular Imaging Society, and fellow-elect of the American Institute of Medical and Biological Engineering.
See this image and copyright information in PMC

Comment on

References

    1. Daldrup-Link HE , Rydland J , Helbich TH , et al. . Quantification of breast tumor microvascular permeability with feruglose-enhanced MR imaging: initial phase II multicenter trial . Radiology 2003. ; 229 ( 3 ): 885 – 892 . - PubMed
    1. Smith BR , Kempen P , Bouley D , et al. . Shape matters: intravital microscopy reveals surprising geometrical dependence for nanoparticles in tumor models of extravasation . Nano Lett 2012. ; 12 ( 7 ): 3369 – 3377 . - PMC - PubMed
    1. Ravi H , Arias-Lorza AM , Costello JR , et al. . Pretherapy Ferumoxytol-enhanced MRI to Predict Response to Liposomal Irinotecan in Metastatic Breast Cancer . Radiol Imaging Cancer 2023. ; 5 ( 2 ): e220022 . - PMC - PubMed
    1. Daldrup-Link HE , Okuhata Y , Wolfe A , et al. . Decrease in tumor apparent permeability-surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulation . Microcirculation 2004. ; 11 ( 5 ): 387 – 396 . - PubMed
    1. Lee H , Shields AF , Siegel BA , et al. . 64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer . Clin Cancer Res 2017. ; 23 ( 15 ): 4190 – 4202 . - PMC - PubMed