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Editorial
. 2023 Feb 1;34(2):179-181.
doi: 10.1681/ASN.0000000000000021. Epub 2023 Jan 17.

Targeting a Single Codon to Rescue Septic Acute Kidney Injury

Guochun Chen  1 , Zheng Dong  2
Affiliations
Editorial

Targeting a Single Codon to Rescue Septic Acute Kidney Injury

Guochun Chen et al. J Am Soc Nephrol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Z. Dong reports Consultancy: DILIsym/RenaSym, Mitobridge; Honoraria: DILIsym/RenaSym; and Advisory or Leadership Role: Associate Editor for American Journal of Physiology—Renal Physiology, Associate Editor for Kidney Diseases, Editorial board member for JASN, Editorial board member for Kidney International, Editorial board member for American Journal of Physiology—Cell Physiology, Board of Directors of Chinese American Society of Nephrology, Adjunct Professorship at The Second Xiangya Hospital of Central South University in China. The remaining author has nothing to disclose.

Figures

Figure 1
Figure 1
Targeting the ISR pathway in septic AKI. In the early phase of sepsis, PKR phosphorylates eIF2α to shut down protein synthesis or translation, whereas in the late phase, eIF2α needs to be dephosphorylated to restore translation for kidney recovery. Inhibition of the ISR pathway, using PKR inhibitors, ISRIB, or genetic modulation of PPP1R15A uORF, may reverse translation shutdown and improve kidney recovery from septic AKI.
See this image and copyright information in PMC

Comment on

References

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