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. 2023 Feb 2;186(3):466-468.
doi: 10.1016/j.cell.2022.12.048.

When IL-17 gets on your nerves

Iliyan D Iliev  1 , Woan-Yu Lin  2 , Sarah L Gaffen  3
Affiliations

When IL-17 gets on your nerves

Iliyan D Iliev et al. Cell. .

Abstract

Microbiota-induced IL-17 production mediates CNS processes and animal behavior. However, its role on the peripheral nervous system (PNS) remains largely unknown. Enamorado et al. demonstrate that commensal-specific Th17 cells are recalled following tissue injury to support local nerve regeneration, a process orchestrated by IL-17 signaling on peripheral neurons.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Fig 1
Fig 1
Commensal-specific Th17 cells support nerve regeneration during skin injury or infection through direct signaling to injured sensory neurons via IL-17RA. S. aureus (SA) topical colonization induces SA-specific Th17 cells that accumulate proximal to dermal neurons. Upon skin injury, cervical DRG2 neurons respond with upregulation of Atf3 and Il17ra. This process fosters neuronal regeneration in an IL-17-dependent manner (right panel) which does not occur in the absence of SA colonization (left panel).
See this image and copyright information in PMC

References

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