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. 2023 Feb 15:82:129167.
doi: 10.1016/j.bmcl.2023.129167. Epub 2023 Feb 2.

Evaluation of carboxylic acid-derivatized corroles as novel gram-positive antibacterial agents under non-photodynamic inactivation conditions

Marc Sautour  1 , Sandrine Pacquelet  2 , Claude P Gros  2 , Nicolas Desbois  3
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Evaluation of carboxylic acid-derivatized corroles as novel gram-positive antibacterial agents under non-photodynamic inactivation conditions

Marc Sautour et al. Bioorg Med Chem Lett. .

Abstract

Herein, we report the synthesis and evaluation of carboxylic acid corroles bearing either one, two, three of four carboxylic groups as gram-positive antibacterial agents against two strains of S. aureus, one methicillin-sensible (MSSA) and the other methicillin-resistant (MRSA). Lead compounds 5 and 6 show low minimum inhibitory concentrations (MICs) of 0.78 μg/mL against both MSSA and MRSA. These molecules, previously underexplored as antibacterial agents, can now serve as a new scaffold for antimicrobial development.

Keywords: Corrole; Gram-positive antibacterial activity; MRSA; MSSA; S. aureus; Structure–activity relationships SAR.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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