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Comment
. 2023 Feb 3;8(1):52.
doi: 10.1038/s41392-023-01320-y.

Metabolic interaction: tumor-derived lactate inhibiting CD8+ T cell cytotoxicity in a novel route

Ke Wang #  1 , Yong Zhang #  2 , Zhi-Nan Chen  3
Affiliations
Comment

Metabolic interaction: tumor-derived lactate inhibiting CD8+ T cell cytotoxicity in a novel route

Ke Wang et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Drugs targeting PDH in clinical trials. a In the absence of lactate, pyruvate may step into PC-mediated metabolic process with accumulated oxaloacetate, which can be converted into PDH pathway by additional lactate from TME. These metabolic outcomes from both enzyme catalytic pathways participate TCA cycles to support energy supplement. DCA and CPI-613, as small molecule targeted drugs, indirectly present positive and negative effects on PDH, respectively. b Several completed clinical trials within pan cancers are listed with clinical phases and NCT numbers
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References

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