Pretomanid-resistant tuberculosis

Niklas Koehler¹, Sönke Andres², Matthias Merker³, Viola Dreyer⁴, Agnieszka John⁵, Martin Kuhns², David Krieger⁶, Eva Choong⁷, Nick Verougstraete⁸, Pia Abel Zur Wiesch⁹, Sebastian G Wicha¹⁰, Christina König¹¹, Barbara Kalsdorf¹, Patricia M Sanchez Carballo¹, Dagmar Schaub¹, Jim Werngren¹², Thomas Schön¹³, Charles A Peloquin¹⁴, Nicolas Schönfeld⁶, Alain G Verstraete¹⁵, Laurent A Decosterd⁷, Rob Aarnoutse¹⁶, Stefan Niemann¹⁷, Florian P Maurer¹⁸, Christoph Lange¹⁹

Affiliations

¹ Department of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Parkallee 35, 23845 Borstel, Germany; German Center for Infection Research (DZIF), Partner Site Borstel-Hamburg-Lübeck-Riems, Parkallee 1-40, 23845 Borstel, Germany; Respiratory Medicine & International Health, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.
² National and World Health Organization Supranational Reference Laboratory for Mycobacteria, Research Center Borstel, Parkallee 18, 23845 Borstel, Germany.
³ German Center for Infection Research (DZIF), Partner Site Borstel-Hamburg-Lübeck-Riems, Parkallee 1-40, 23845 Borstel, Germany; Evolution of the Resistome, Research Center Borstel, Parkallee 1, 23845 Borstel, Germany.
⁴ German Center for Infection Research (DZIF), Partner Site Borstel-Hamburg-Lübeck-Riems, Parkallee 1-40, 23845 Borstel, Germany; Molecular and Experimental Mycobacteriology, National Reference Center for Mycobacteria, Research Center Borstel, Parkallee 1, 23845 Borstel, Germany.
⁵ Department of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Parkallee 35, 23845 Borstel, Germany.
⁶ Department of Pulmonology, Lungenklinik Heckeshorn, HELIOS Klinikum Emil von Behring, Walterhöferstraße 11, 14165 Berlin, Germany.
⁷ Laboratory of Clinical Pharmacology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland.
⁸ Department of Laboratory Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
⁹ Department of Pharmacy, Faculty of Health Sciences, UiT - The Arctic University of Norway, Hansine Hansens veg 18, 9019 Tromsø, Norway; Centre for Molecular Medicine Norway, Nordic EMBL Partnership, Forskningsparken, Gaustadalléen 21, 0349 Oslo, Norway; Department of Biology, The Pennsylvania State University, University Park Pennsylvania, Mueller Laboratory, 208 Curtin Rd, State College, PA 16801, USA; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park Pennsylvania, 101 Huck Life Sciences Building, University Park, PA 16802, USA.
¹⁰ Institute of Pharmacy, University of Hamburg, Bundesstraße 45, 20146 Hamburg, Germany.
¹¹ Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinstraße 52, 20246 Hamburg, Germany; Department of Pharmacy, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20251 Hamburg, Germany.
¹² Department of Microbiology, Unit for Laboratory Surveillance of Bacterial Pathogens, Public Health Agency of Sweden, Nobels väg 18, 171 65 Solna, Sweden.
¹³ Department of Infectious Diseases, Linköping University Hospital, Universitetssjukhuset, 581 85 Linköping, Sweden; Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Universitetssjukhuset, 581 85 Linköping, Sweden.
¹⁴ Infectious Disease Pharmacokinetics Laboratory, Emerging Pathogens Institute, University of Florida, 2055 Mowry Rd, Gainesville, FL 32610, USA; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, 1225 Center Dr, Gainesville, FL 32610, USA.
¹⁵ Department of Laboratory Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium; Department of Diagnostic Sciences, Ghent University, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
¹⁶ Department of Pharmacy, Radboud University Medical Center, Radboud Institute for Health Sciences, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands.
¹⁷ German Center for Infection Research (DZIF), Partner Site Borstel-Hamburg-Lübeck-Riems, Parkallee 1-40, 23845 Borstel, Germany; National and World Health Organization Supranational Reference Laboratory for Mycobacteria, Research Center Borstel, Parkallee 18, 23845 Borstel, Germany; Molecular and Experimental Mycobacteriology, National Reference Center for Mycobacteria, Research Center Borstel, Parkallee 1, 23845 Borstel, Germany.
¹⁸ National and World Health Organization Supranational Reference Laboratory for Mycobacteria, Research Center Borstel, Parkallee 18, 23845 Borstel, Germany; Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Martinstraße 52, 20246 Hamburg, Germany.
¹⁹ Department of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Parkallee 35, 23845 Borstel, Germany; German Center for Infection Research (DZIF), Partner Site Borstel-Hamburg-Lübeck-Riems, Parkallee 1-40, 23845 Borstel, Germany; Respiratory Medicine & International Health, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany; Baylor College of Medicine and Texas Childrens' Hospital, 1 Baylor Plaza, Houston, TX 77030, USA. Electronic address: clange@fz-borstel.de.

PMID: 36738862
DOI: 10.1016/j.jinf.2023.01.039

Comment

Pretomanid-resistant tuberculosis

Niklas Koehler et al. J Infect. 2023 May.

. 2023 May;86(5):520-524.

doi: 10.1016/j.jinf.2023.01.039. Epub 2023 Feb 2.

Authors

Affiliations

¹ Department of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Parkallee 35, 23845 Borstel, Germany; German Center for Infection Research (DZIF), Partner Site Borstel-Hamburg-Lübeck-Riems, Parkallee 1-40, 23845 Borstel, Germany; Respiratory Medicine & International Health, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.
² National and World Health Organization Supranational Reference Laboratory for Mycobacteria, Research Center Borstel, Parkallee 18, 23845 Borstel, Germany.
³ German Center for Infection Research (DZIF), Partner Site Borstel-Hamburg-Lübeck-Riems, Parkallee 1-40, 23845 Borstel, Germany; Evolution of the Resistome, Research Center Borstel, Parkallee 1, 23845 Borstel, Germany.
⁴ German Center for Infection Research (DZIF), Partner Site Borstel-Hamburg-Lübeck-Riems, Parkallee 1-40, 23845 Borstel, Germany; Molecular and Experimental Mycobacteriology, National Reference Center for Mycobacteria, Research Center Borstel, Parkallee 1, 23845 Borstel, Germany.
⁵ Department of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Parkallee 35, 23845 Borstel, Germany.
⁶ Department of Pulmonology, Lungenklinik Heckeshorn, HELIOS Klinikum Emil von Behring, Walterhöferstraße 11, 14165 Berlin, Germany.
⁷ Laboratory of Clinical Pharmacology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland.
⁸ Department of Laboratory Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
⁹ Department of Pharmacy, Faculty of Health Sciences, UiT - The Arctic University of Norway, Hansine Hansens veg 18, 9019 Tromsø, Norway; Centre for Molecular Medicine Norway, Nordic EMBL Partnership, Forskningsparken, Gaustadalléen 21, 0349 Oslo, Norway; Department of Biology, The Pennsylvania State University, University Park Pennsylvania, Mueller Laboratory, 208 Curtin Rd, State College, PA 16801, USA; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park Pennsylvania, 101 Huck Life Sciences Building, University Park, PA 16802, USA.
¹⁰ Institute of Pharmacy, University of Hamburg, Bundesstraße 45, 20146 Hamburg, Germany.
¹¹ Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinstraße 52, 20246 Hamburg, Germany; Department of Pharmacy, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20251 Hamburg, Germany.
¹² Department of Microbiology, Unit for Laboratory Surveillance of Bacterial Pathogens, Public Health Agency of Sweden, Nobels väg 18, 171 65 Solna, Sweden.
¹³ Department of Infectious Diseases, Linköping University Hospital, Universitetssjukhuset, 581 85 Linköping, Sweden; Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Universitetssjukhuset, 581 85 Linköping, Sweden.
¹⁴ Infectious Disease Pharmacokinetics Laboratory, Emerging Pathogens Institute, University of Florida, 2055 Mowry Rd, Gainesville, FL 32610, USA; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, 1225 Center Dr, Gainesville, FL 32610, USA.
¹⁵ Department of Laboratory Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium; Department of Diagnostic Sciences, Ghent University, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
¹⁶ Department of Pharmacy, Radboud University Medical Center, Radboud Institute for Health Sciences, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands.
¹⁷ German Center for Infection Research (DZIF), Partner Site Borstel-Hamburg-Lübeck-Riems, Parkallee 1-40, 23845 Borstel, Germany; National and World Health Organization Supranational Reference Laboratory for Mycobacteria, Research Center Borstel, Parkallee 18, 23845 Borstel, Germany; Molecular and Experimental Mycobacteriology, National Reference Center for Mycobacteria, Research Center Borstel, Parkallee 1, 23845 Borstel, Germany.
¹⁸ National and World Health Organization Supranational Reference Laboratory for Mycobacteria, Research Center Borstel, Parkallee 18, 23845 Borstel, Germany; Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Martinstraße 52, 20246 Hamburg, Germany.
¹⁹ Department of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Parkallee 35, 23845 Borstel, Germany; German Center for Infection Research (DZIF), Partner Site Borstel-Hamburg-Lübeck-Riems, Parkallee 1-40, 23845 Borstel, Germany; Respiratory Medicine & International Health, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany; Baylor College of Medicine and Texas Childrens' Hospital, 1 Baylor Plaza, Houston, TX 77030, USA. Electronic address: clange@fz-borstel.de.

PMID: 36738862
DOI: 10.1016/j.jinf.2023.01.039

No abstract available

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Conflict of interest statement

Declaration of Competing Interest C.K. received personal fees from INFECTOPHARM outside the scope of this work; C.K. received speakers honoraria from GILEAD and SHIONOGI outside the scope of this work; B.K. received personal fees from INSMED outside the scope of this work; S.N. received grants from German Center for Infection Research, Excellence Cluster Precision Medicine in Chronic Inflammation EXC 2167, and Leibniz Science Campus Evolutionary Medicine of the LUNG (EvoLUNG), during the conduct of the study; S.N. received consultation fees from ILLUMINA outside the scope of this work; C.L. received consulting fees from INSMED outside the scope of this work; C.L. received speakers honoraria from INSMED, GILEAD, and JANSSEN outside the scope of this work; C.L. is a participant on Data Safety Boards of Medicines sans Frontiers outside the scope of this work; all other authors have nothing to disclose.

Comment on

Proteomic analysis of sequential isolates of multidrug-resistant Mycobacterium tuberculosis during treatment failure.
Lee DG, Kim HJ, Park MJ, Hong JH, Ryoo S. Lee DG, et al. J Infect. 2022 Nov;85(5):e137-e139. doi: 10.1016/j.jinf.2022.08.010. Epub 2022 Aug 17. J Infect. 2022. PMID: 35987390 No abstract available.

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Pretomanid-resistant tuberculosis

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Pretomanid-resistant tuberculosis

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