Randomized Controlled Trial
doi: 10.1016/j.wneu.2023.01.098.
Epub 2023 Feb 3.
Patient Selection in a Pragmatic Study on the Management of Patients with Brain Arteriovenous Malformations
Jean Raymond
1
, Anass Benomar
2
, Jean-Christophe Gentric
3
, Elsa Magro
4
, Lorena Nico
5
, Emma Bacchus
6
, Ruby Klink
7
, Daniela Iancu
2
, Alain Weill
2
, Daniel Roy
2
, Michel W Bojanowski
8
, Chiraz Chaalala
8
, Omer Eker
9
, Isabelle Pelissou-Guyotat
10
, Michel Piotin
11
, Sorin Aldea
12
, Charlotte Barbier
13
, Thomas Gaberel
14
, Chrysanthi Papagiannaki
15
, Stéphane Derrey
16
, Thanh N Nguyen
17
, Mohamad Abdalkader
18
, Christophe Cognard
19
, Anne-Christine Januel
19
, Jean-François Sabatier
20
, Vincent Jecko
21
, Xavier Barreau
22
, Vincent Costalat
23
, Marine Le Corre
24
, Jean-Yves Gauvrit
25
, Xavier Morandi
26
, Alessandra Biondi
27
, Laurent Thines
28
, Hubert Desal
29
, Romain Bourcier
29
, Rémy Beaujeux
30
, François Proust
31
, Geraldine Viard
32
, Guylaine Gevry
7
, Tim E Darsaut
6
; TOBAS Collaborative Group
Collaborators,
Affiliations
Collaborators
-
TOBAS Collaborative Group:
Jean Raymond 33 , Daniel Roy 33 , Alain Weill 33 , Daniela Iancu 33 , Michel W Bojanowski 34 , Chiraz Chaalala 34 , Tim E Darsaut 35 , Cian J O'Kelly 35 , Michael Mc Chow 35 , J Max Findlay 35 , Jeremy L Rempel 36 , Robert Fahed 37 , Howard Lesiuk 38 , Brian Drake 38 , Marlene Dos Santos 39 , Jean-Christophe Gentric 40 , Michel Nonent 40 , Julien Ognard 40 , Mourad Cheddad El-Aouni 40 , Elsa Magro 41 , Romuald Seizeur 41 , Serge Timsit 42 , Olivier Pradier 43 , Hubert Desal 44 , Romain Boursier 44 , François Thillays 45 , Vincent Roualdes 46 , Michel Piotin 47 , Raphael Blanc 47 , Sorin Aldea 48 , Christophe Cognard 49 , Anne-Christine Januel 49 , Jean-François Sabatier 50 , Lionel Calviere 51 , Jean Yves Gauvrit 52 , Hélène Raoult 52 , François Eugene 52 , Anthony Le Bras 52 , Jean-Christophe Ferre 52 , Christophe Paya 52 , Xavier Morandi 53 , Isabelle Lecouillard 54 , Elodie Nouhaud 54 , Thomas Ronziere 55 , Denis Trystram 56 , Olivier Naggara 56 , Christine Rodriguez-Regent 56 , Basile Kerleroux 56 , Charlotte Barbier 57 , Thomas Gaberel 58 , Evelyne Emery 58 , Emmanuel Touze 59 , Chrysanthi Papagiannaki 60 , Stéphane Derrey 61 , Omer Eker 62 , Roberto Riva 62 , Isabelle Pellisou-Guyotat 63 , Jacques Guyotat 63 , Monsef Berhouma 63 , Chloé Dumot 63 , Alessandra Biondi 64 , Laurent Thines 65 , Nassim Bougaci 65 , Guillaume Charbonnier 66 , Serge Bracard 67 , René Anxionnat 67 , Benjamin Gory 67 , Thierry Civit 68 , Valérie Bernier-Chastagner 69 , Xavier Barreau 70 , Gaultier Marnat 70 , Vincent Jecko 71 , Guillaume Penchet 71 , Edouard Gimbert 71 , Aymeri Huchet 72 , Denis Herbreteau 73 , Grégoire Boulouis 73 , Richard Bibi 73 , Héloïse Ifergan 73 , Kévin Janot 73 , Stéphane Velut 74 , Hervé Brunel 75 , Pierre-Hugues Roche 76 , Thomas Graillon 76 , Hadrien Peyriere 76 , Jean-Marc Kaya 76 , Adamou Touta 76 , Lucas Troude 76 , Sébastien Boissonneau 76 , Frédéric Clarençon 77 , Eimad Shotar 77 , Nader Sourour 77 , Stéphanie Lenck 77 , Kévin Premat 77 , Anne-Laure Boch 78 , Philippe Cornu 78 , Aurélien Nouet 78 , Vincent Costalat 79 , Alain Bonafe 79 , Cyril Dargazanli 79 , Gregory Gascou 79 , Pierre-Henri Lefevre 79 , Carlos Riquelme 79 , Marine Le Corre 80 , Rémy Beaujeux 81 , Raoul Pop 81 , François Proust 82 , Hélène Cebula 82 , Irène Ollivier 82 , Giorgio Spatola 82 , Laurent Spell 83 , Vanessa Chalumeau 83 , Sophie Gallas 83 , Léon Ikka 83 , Cristian Mihalea 83 , Augustin Ozanne 83 , Jildaz Caroff 83 , Emmanuel Chabert 84 , Charbel Mounayer 85 , Aymeric Rouchaud 85 , François Caire 86 , Frédéric Ricolfi 87 , Pierre Thouant 87 , Catherine Cao 88 , Klaus-Luc Mourier 88 , Walid Farah 88 , Thanh N Nguyen 89 , Mohamad Abdalkader 89 , Thien Huynh 90 , Rabih G Tawk 91 , Andrew P Carlson 92 , Luciana Alves Oliveira Silva 93 , Nayara de Lima Froio 93 , Gisele Sampaio Silva 93 , Francisco J A Mont'Alverne 94 , Jose Luri Martins 94 , George Nunes Mendes 94 , Rodrigo Rivera Miranda 95
Affiliations
- 1 Department of Radiology, Service of Neuroradiology, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada. Electronic address: jean.raymond@umontreal.ca.
- 2 Department of Radiology, Service of Neuroradiology, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada.
- 3 Service de Neuroradiologie, CHU Cavale Blanche, EA 3878 GETBO, Brest, France.
- 4 Service de Neurochirurgie, CHU Cavale Blanche, INSERM UMR 1101 LaTIM, Brest, France.
- 5 Service de Neuroradiologie Interventionnelle, CHU Saint-Etienne, Saint-Étienne, France.
- 6 Division of Neurosurgery, Department of Surgery, University of Alberta Hospital, Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada.
- 7 Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Laboratoire de Recherche en NeuroRadiologie Interventionnelle (NRI), Montreal, Quebec, Canada.
- 8 Division of Neurosurgery, Department of Surgery, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada.
- 9 Service d'imagerie neurologique diagnostique et interventionnelle, Hôpital neurologique Pierre Wertheimer, Hospices civils de Lyon, Lyon, France.
- 10 Service de Neurochirurgie Tumorale et Vasculaire, Hôpital neurologique Pierre Wertheimer, Hospices civils de Lyon, Lyon, France.
- 11 Service de Neuroradiologie Interventionnelle, Hôpital Fondation Adolphe de Rothschild, Paris, France.
- 12 Service de Neurochirurgie, Hôpital Fondation Adolphe de Rothschild, Paris, France.
- 13 Service d'imagerie vasculaire et Interventionnelle, CHU Caen Normandie, Caen, France.
- 14 Service de neurochirurgie, CHU Caen Normandie, Caen, France.
- 15 Service de Radiologie, Hôpital Charles Nicolle, CHU Rouen Normandie, Rouen France.
- 16 Service de Neurochirurgie, Hôpital Charles Nicolle, CHU Rouen Normandie, Rouen France.
- 17 Department of Radiology, Department of Neurology, Department of Neurosurgery, Boston Medical Center, Boston University-School of Medicine, Boston, USA.
- 18 Department of Radiology, Boston Medical Center, Boston University-School of Medicine, Boston, USA.
- 19 Service de Neuroradiolgie diagnostique et thérapeutique, Hôpital Pierre-Paul Riquet, CHU de Toulouse, France.
- 20 Service de Neurochirurgie, Hôpital Pierre-Paul Riquet, CHU de Toulouse, Toulouse, France.
- 21 Service de Neurochirurgie A, Groupe Hospitalier Pellegrin, CHU Bordeaux, Bordeaux France.
- 22 Service de Neuroradiologie Diagnostique et Thérapeutique, Groupe Hospitalier Pellegrin, CHU Bordeaux, Bordeaux France.
- 23 Service de Neuroradiologie, CHU Montpellier, Montpellier, France.
- 24 Service de Neurochirurgie, CHU Montpellier, Montpellier, France.
- 25 Service de neuroradiologie, Hôpital Pontchaillou, CHU Rennes, Rennes, France.
- 26 Service de neurochirurgie, Hôpital Pontchaillou, CHU Rennes, Rennes, France.
- 27 Department of Interventional Neuroradiology, University Hospital Centre Besancon, Besancon, France.
- 28 Department of Neurosurgery, University Hospital Jean Minjoz, Besançon, France.
- 29 Department of Neuroradiology, University Hospital of Nantes, Nantes, France.
- 30 Service de Neuroradiologie Interventionnelle,Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
- 31 Service de Neurochirurgie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
- 32 Centre d'investigation Clinique, CHU Brest, Brest, France.
- 33 Department of Radiology, Interventional Neuroradiology Service, Centre hospitalier de l'Université de Montréal (CHUM), Montreal, Canada.
- 34 Neurosurgery Service, Centre hospitalier de l'Université de Montréal (CHUM), Montreal, Canada.
- 35 Division of Neurosurgery, University of Alberta hospital, Edmonton, Canada.
- 36 Department of Radiology, Interventional Neuroradiology Service, University of Alberta hospital, Edmonton, Canada.
- 37 Department of Neurology, The Ottawa hospital, Ottawa, Canada.
- 38 Division of Neurosurgery, The Ottawa hospital, Ottawa, Canada.
- 39 Department of Radiology, Interventional Neuroradiology Service, The Ottawa hospital, Ottawa, Canada.
- 40 Department of Radiology, Interventional Neuroradiology Service, CHU de Brest, Brest, France.
- 41 Neurosurgery Service, CHU de Brest, Brest, France.
- 42 Department of Neurology, CHU de Brest, Brest, France.
- 43 Radio-oncology Department, CHU de Brest, Brest, France.
- 44 Department of Radiology, Interventional Neuroradiology Service, CHU de Nantes, Nantes, France.
- 45 Radio-oncology Department, CHU de Nantes, Nantes, France.
- 46 Neurosurgery Service, CHU de Nantes, Nantes, France.
- 47 Department of Radiology, Interventional Neuroradiology Service, Fondation Ophthalmique Rothschild, Paris, France.
- 48 Neurosurgery Service, Fondation Ophthalmique Rothschild, Paris, France.
- 49 Department of Radiology, Interventional Neuroradiology Service, CHU de Toulouse, Toulouse, France.
- 50 Neurosurgery Service, CHU de Toulouse, Toulouse, France.
- 51 Department of Neurology, CHU de Toulouse, Toulouse, France.
- 52 Department of Radiology, Interventional Neuroradiology Service, CHU de Rennes, Rennes, France.
- 53 Neurosurgery Service, CHU de Rennes, Rennes, France.
- 54 Radio-oncology Department, CHU de Rennes, Rennes, France.
- 55 Department of Neurology, CHU de Rennes, Rennes, France.
- 56 Department of Radiology, Interventional Neuroradiology Service, CHU Ste-Anne, Paris, France.
- 57 Department of Radiology, Interventional Neuroradiology Service, CHU de Caen, Caen, France.
- 58 Neurosurgery Service, CHU de Caen, Caen, France.
- 59 Neurology Service, CHU de Caen, Caen, France.
- 60 Department of Radiology, Interventional Neuroradiology Service, CHU de Rouen, Rouen, France.
- 61 Neurosurgery Service, CHU de Rouen, Rouen, France.
- 62 Department of Radiology, Interventional Neuroradiology Service, CHU de Lyon, Lyon, France.
- 63 Neurosurgery Service, CHU de Lyon, Lyon, France.
- 64 Department of Radiology, Interventional Neuroradiology Service, CHRU de Besançon, Besançon, France.
- 65 Neurosurgery Service, CHRU de Besançon, Besançon, France.
- 66 Neurology Service, CHRU de Besançon, Besançon, France.
- 67 Department of Radiology, Interventional Neuroradiology Service, CHRU de Nancy, Nancy, France.
- 68 Neurosurgery Service, CHRU de Nancy, Nancy, France.
- 69 Radio-oncology Department, CHRU de Nancy, Nancy, France.
- 70 Department of Radiology, Interventional Neuroradiology Service, CHU de Bordeaux, Bordeaux, France.
- 71 Neurosurgery Service, CHU de Bordeaux, Bordeaux, France.
- 72 Radio-oncology Department, CHU de Bordeaux, Bordeaux, France.
- 73 Department of Radiology, Interventional Neuroradiology Service, CHRU de Tours, Tours, France.
- 74 Neurosurgery Service, CHRU de Tours, Tours, France.
- 75 Department of Radiology, Interventional Neuroradiology Service, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
- 76 Neurosurgery Service, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
- 77 Department of Radiology, Interventional Neuroradiology Service, Hôpital Universitaire Pitié-Salpêtrière, Paris, France.
- 78 Neurosurgery Service, Hôpital Universitaire Pitié-Salpêtrière, Paris, France.
- 79 Department of Radiology, Interventional Neuroradiology Service, CHU de Montpellier, Montpellier, France.
- 80 Neurosurgery Service, CHU de Montpellier, Montpellier, France.
- 81 Department of Radiology, Interventional Neuroradiology Service, CHU de Strasbourg, Strasbourg, France.
- 82 Neurosurgery Service, CHU de Strasbourg, Strasbourg, France.
- 83 Department of Radiology, Interventional Neuroradiology Service, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
- 84 Department of Radiology, Interventional Neuroradiology Service, CHU de Clermont-Ferrand, Clermont-Ferrand, France.
- 85 Department of Radiology, Interventional Neuroradiology Service, CHU de Limoges, Limoges, France.
- 86 Neurosurgery Service, CHU de Limoges, Limoges, France.
- 87 Department of Radiology, Interventional Neuroradiology Service, CHU de Dijon, Dijon, France.
- 88 Neurosurgery Service, CHU de Dijon, Dijon, France.
- 89 Department of Radiology, Interventional Neuroradiology Service, Boston Medical Centre, Boston, United States.
- 90 Department of Radiology, Interventional Neuroradiology Service, Mayo Clinics, Jacksonville, United States.
- 91 Neurosurgery Service, Mayo Clinics, Jacksonville, United States.
- 92 Neurosurgery Service, University of New Mexico Health Sciences Center, New Mexico, USA.
- 93 Neurology Department, Universidade Federal de São Paulo, São Paulo, Brazil.
- 94 Interventional Neuroradiology Service, Hospital Geral de Fortaleza, Fortaleza, Brazil.
- 95 Interventional Neuroradiology Service, Instituto de Neurocirugia Dr Alfonso Asenjo, Santiago, Chile.
- PMID: 36738962
- DOI: 10.1016/j.wneu.2023.01.098
Item in Clipboard
Randomized Controlled Trial
Patient Selection in a Pragmatic Study on the Management of Patients with Brain Arteriovenous Malformations
Jean Raymond et al.
World Neurosurg.
2023 Apr.
Display options
Format
doi: 10.1016/j.wneu.2023.01.098.
Epub 2023 Feb 3.
Authors
Jean Raymond
1
, Anass Benomar
2
, Jean-Christophe Gentric
3
, Elsa Magro
4
, Lorena Nico
5
, Emma Bacchus
6
, Ruby Klink
7
, Daniela Iancu
2
, Alain Weill
2
, Daniel Roy
2
, Michel W Bojanowski
8
, Chiraz Chaalala
8
, Omer Eker
9
, Isabelle Pelissou-Guyotat
10
, Michel Piotin
11
, Sorin Aldea
12
, Charlotte Barbier
13
, Thomas Gaberel
14
, Chrysanthi Papagiannaki
15
, Stéphane Derrey
16
, Thanh N Nguyen
17
, Mohamad Abdalkader
18
, Christophe Cognard
19
, Anne-Christine Januel
19
, Jean-François Sabatier
20
, Vincent Jecko
21
, Xavier Barreau
22
, Vincent Costalat
23
, Marine Le Corre
24
, Jean-Yves Gauvrit
25
, Xavier Morandi
26
, Alessandra Biondi
27
, Laurent Thines
28
, Hubert Desal
29
, Romain Bourcier
29
, Rémy Beaujeux
30
, François Proust
31
, Geraldine Viard
32
, Guylaine Gevry
7
, Tim E Darsaut
6
; TOBAS Collaborative Group
Collaborators
-
TOBAS Collaborative Group:
Jean Raymond 33 , Daniel Roy 33 , Alain Weill 33 , Daniela Iancu 33 , Michel W Bojanowski 34 , Chiraz Chaalala 34 , Tim E Darsaut 35 , Cian J O'Kelly 35 , Michael Mc Chow 35 , J Max Findlay 35 , Jeremy L Rempel 36 , Robert Fahed 37 , Howard Lesiuk 38 , Brian Drake 38 , Marlene Dos Santos 39 , Jean-Christophe Gentric 40 , Michel Nonent 40 , Julien Ognard 40 , Mourad Cheddad El-Aouni 40 , Elsa Magro 41 , Romuald Seizeur 41 , Serge Timsit 42 , Olivier Pradier 43 , Hubert Desal 44 , Romain Boursier 44 , François Thillays 45 , Vincent Roualdes 46 , Michel Piotin 47 , Raphael Blanc 47 , Sorin Aldea 48 , Christophe Cognard 49 , Anne-Christine Januel 49 , Jean-François Sabatier 50 , Lionel Calviere 51 , Jean Yves Gauvrit 52 , Hélène Raoult 52 , François Eugene 52 , Anthony Le Bras 52 , Jean-Christophe Ferre 52 , Christophe Paya 52 , Xavier Morandi 53 , Isabelle Lecouillard 54 , Elodie Nouhaud 54 , Thomas Ronziere 55 , Denis Trystram 56 , Olivier Naggara 56 , Christine Rodriguez-Regent 56 , Basile Kerleroux 56 , Charlotte Barbier 57 , Thomas Gaberel 58 , Evelyne Emery 58 , Emmanuel Touze 59 , Chrysanthi Papagiannaki 60 , Stéphane Derrey 61 , Omer Eker 62 , Roberto Riva 62 , Isabelle Pellisou-Guyotat 63 , Jacques Guyotat 63 , Monsef Berhouma 63 , Chloé Dumot 63 , Alessandra Biondi 64 , Laurent Thines 65 , Nassim Bougaci 65 , Guillaume Charbonnier 66 , Serge Bracard 67 , René Anxionnat 67 , Benjamin Gory 67 , Thierry Civit 68 , Valérie Bernier-Chastagner 69 , Xavier Barreau 70 , Gaultier Marnat 70 , Vincent Jecko 71 , Guillaume Penchet 71 , Edouard Gimbert 71 , Aymeri Huchet 72 , Denis Herbreteau 73 , Grégoire Boulouis 73 , Richard Bibi 73 , Héloïse Ifergan 73 , Kévin Janot 73 , Stéphane Velut 74 , Hervé Brunel 75 , Pierre-Hugues Roche 76 , Thomas Graillon 76 , Hadrien Peyriere 76 , Jean-Marc Kaya 76 , Adamou Touta 76 , Lucas Troude 76 , Sébastien Boissonneau 76 , Frédéric Clarençon 77 , Eimad Shotar 77 , Nader Sourour 77 , Stéphanie Lenck 77 , Kévin Premat 77 , Anne-Laure Boch 78 , Philippe Cornu 78 , Aurélien Nouet 78 , Vincent Costalat 79 , Alain Bonafe 79 , Cyril Dargazanli 79 , Gregory Gascou 79 , Pierre-Henri Lefevre 79 , Carlos Riquelme 79 , Marine Le Corre 80 , Rémy Beaujeux 81 , Raoul Pop 81 , François Proust 82 , Hélène Cebula 82 , Irène Ollivier 82 , Giorgio Spatola 82 , Laurent Spell 83 , Vanessa Chalumeau 83 , Sophie Gallas 83 , Léon Ikka 83 , Cristian Mihalea 83 , Augustin Ozanne 83 , Jildaz Caroff 83 , Emmanuel Chabert 84 , Charbel Mounayer 85 , Aymeric Rouchaud 85 , François Caire 86 , Frédéric Ricolfi 87 , Pierre Thouant 87 , Catherine Cao 88 , Klaus-Luc Mourier 88 , Walid Farah 88 , Thanh N Nguyen 89 , Mohamad Abdalkader 89 , Thien Huynh 90 , Rabih G Tawk 91 , Andrew P Carlson 92 , Luciana Alves Oliveira Silva 93 , Nayara de Lima Froio 93 , Gisele Sampaio Silva 93 , Francisco J A Mont'Alverne 94 , Jose Luri Martins 94 , George Nunes Mendes 94 , Rodrigo Rivera Miranda 95
Affiliations
- 1 Department of Radiology, Service of Neuroradiology, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada. Electronic address: jean.raymond@umontreal.ca.
- 2 Department of Radiology, Service of Neuroradiology, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada.
- 3 Service de Neuroradiologie, CHU Cavale Blanche, EA 3878 GETBO, Brest, France.
- 4 Service de Neurochirurgie, CHU Cavale Blanche, INSERM UMR 1101 LaTIM, Brest, France.
- 5 Service de Neuroradiologie Interventionnelle, CHU Saint-Etienne, Saint-Étienne, France.
- 6 Division of Neurosurgery, Department of Surgery, University of Alberta Hospital, Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada.
- 7 Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Laboratoire de Recherche en NeuroRadiologie Interventionnelle (NRI), Montreal, Quebec, Canada.
- 8 Division of Neurosurgery, Department of Surgery, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada.
- 9 Service d'imagerie neurologique diagnostique et interventionnelle, Hôpital neurologique Pierre Wertheimer, Hospices civils de Lyon, Lyon, France.
- 10 Service de Neurochirurgie Tumorale et Vasculaire, Hôpital neurologique Pierre Wertheimer, Hospices civils de Lyon, Lyon, France.
- 11 Service de Neuroradiologie Interventionnelle, Hôpital Fondation Adolphe de Rothschild, Paris, France.
- 12 Service de Neurochirurgie, Hôpital Fondation Adolphe de Rothschild, Paris, France.
- 13 Service d'imagerie vasculaire et Interventionnelle, CHU Caen Normandie, Caen, France.
- 14 Service de neurochirurgie, CHU Caen Normandie, Caen, France.
- 15 Service de Radiologie, Hôpital Charles Nicolle, CHU Rouen Normandie, Rouen France.
- 16 Service de Neurochirurgie, Hôpital Charles Nicolle, CHU Rouen Normandie, Rouen France.
- 17 Department of Radiology, Department of Neurology, Department of Neurosurgery, Boston Medical Center, Boston University-School of Medicine, Boston, USA.
- 18 Department of Radiology, Boston Medical Center, Boston University-School of Medicine, Boston, USA.
- 19 Service de Neuroradiolgie diagnostique et thérapeutique, Hôpital Pierre-Paul Riquet, CHU de Toulouse, France.
- 20 Service de Neurochirurgie, Hôpital Pierre-Paul Riquet, CHU de Toulouse, Toulouse, France.
- 21 Service de Neurochirurgie A, Groupe Hospitalier Pellegrin, CHU Bordeaux, Bordeaux France.
- 22 Service de Neuroradiologie Diagnostique et Thérapeutique, Groupe Hospitalier Pellegrin, CHU Bordeaux, Bordeaux France.
- 23 Service de Neuroradiologie, CHU Montpellier, Montpellier, France.
- 24 Service de Neurochirurgie, CHU Montpellier, Montpellier, France.
- 25 Service de neuroradiologie, Hôpital Pontchaillou, CHU Rennes, Rennes, France.
- 26 Service de neurochirurgie, Hôpital Pontchaillou, CHU Rennes, Rennes, France.
- 27 Department of Interventional Neuroradiology, University Hospital Centre Besancon, Besancon, France.
- 28 Department of Neurosurgery, University Hospital Jean Minjoz, Besançon, France.
- 29 Department of Neuroradiology, University Hospital of Nantes, Nantes, France.
- 30 Service de Neuroradiologie Interventionnelle,Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
- 31 Service de Neurochirurgie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
- 32 Centre d'investigation Clinique, CHU Brest, Brest, France.
- 33 Department of Radiology, Interventional Neuroradiology Service, Centre hospitalier de l'Université de Montréal (CHUM), Montreal, Canada.
- 34 Neurosurgery Service, Centre hospitalier de l'Université de Montréal (CHUM), Montreal, Canada.
- 35 Division of Neurosurgery, University of Alberta hospital, Edmonton, Canada.
- 36 Department of Radiology, Interventional Neuroradiology Service, University of Alberta hospital, Edmonton, Canada.
- 37 Department of Neurology, The Ottawa hospital, Ottawa, Canada.
- 38 Division of Neurosurgery, The Ottawa hospital, Ottawa, Canada.
- 39 Department of Radiology, Interventional Neuroradiology Service, The Ottawa hospital, Ottawa, Canada.
- 40 Department of Radiology, Interventional Neuroradiology Service, CHU de Brest, Brest, France.
- 41 Neurosurgery Service, CHU de Brest, Brest, France.
- 42 Department of Neurology, CHU de Brest, Brest, France.
- 43 Radio-oncology Department, CHU de Brest, Brest, France.
- 44 Department of Radiology, Interventional Neuroradiology Service, CHU de Nantes, Nantes, France.
- 45 Radio-oncology Department, CHU de Nantes, Nantes, France.
- 46 Neurosurgery Service, CHU de Nantes, Nantes, France.
- 47 Department of Radiology, Interventional Neuroradiology Service, Fondation Ophthalmique Rothschild, Paris, France.
- 48 Neurosurgery Service, Fondation Ophthalmique Rothschild, Paris, France.
- 49 Department of Radiology, Interventional Neuroradiology Service, CHU de Toulouse, Toulouse, France.
- 50 Neurosurgery Service, CHU de Toulouse, Toulouse, France.
- 51 Department of Neurology, CHU de Toulouse, Toulouse, France.
- 52 Department of Radiology, Interventional Neuroradiology Service, CHU de Rennes, Rennes, France.
- 53 Neurosurgery Service, CHU de Rennes, Rennes, France.
- 54 Radio-oncology Department, CHU de Rennes, Rennes, France.
- 55 Department of Neurology, CHU de Rennes, Rennes, France.
- 56 Department of Radiology, Interventional Neuroradiology Service, CHU Ste-Anne, Paris, France.
- 57 Department of Radiology, Interventional Neuroradiology Service, CHU de Caen, Caen, France.
- 58 Neurosurgery Service, CHU de Caen, Caen, France.
- 59 Neurology Service, CHU de Caen, Caen, France.
- 60 Department of Radiology, Interventional Neuroradiology Service, CHU de Rouen, Rouen, France.
- 61 Neurosurgery Service, CHU de Rouen, Rouen, France.
- 62 Department of Radiology, Interventional Neuroradiology Service, CHU de Lyon, Lyon, France.
- 63 Neurosurgery Service, CHU de Lyon, Lyon, France.
- 64 Department of Radiology, Interventional Neuroradiology Service, CHRU de Besançon, Besançon, France.
- 65 Neurosurgery Service, CHRU de Besançon, Besançon, France.
- 66 Neurology Service, CHRU de Besançon, Besançon, France.
- 67 Department of Radiology, Interventional Neuroradiology Service, CHRU de Nancy, Nancy, France.
- 68 Neurosurgery Service, CHRU de Nancy, Nancy, France.
- 69 Radio-oncology Department, CHRU de Nancy, Nancy, France.
- 70 Department of Radiology, Interventional Neuroradiology Service, CHU de Bordeaux, Bordeaux, France.
- 71 Neurosurgery Service, CHU de Bordeaux, Bordeaux, France.
- 72 Radio-oncology Department, CHU de Bordeaux, Bordeaux, France.
- 73 Department of Radiology, Interventional Neuroradiology Service, CHRU de Tours, Tours, France.
- 74 Neurosurgery Service, CHRU de Tours, Tours, France.
- 75 Department of Radiology, Interventional Neuroradiology Service, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
- 76 Neurosurgery Service, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
- 77 Department of Radiology, Interventional Neuroradiology Service, Hôpital Universitaire Pitié-Salpêtrière, Paris, France.
- 78 Neurosurgery Service, Hôpital Universitaire Pitié-Salpêtrière, Paris, France.
- 79 Department of Radiology, Interventional Neuroradiology Service, CHU de Montpellier, Montpellier, France.
- 80 Neurosurgery Service, CHU de Montpellier, Montpellier, France.
- 81 Department of Radiology, Interventional Neuroradiology Service, CHU de Strasbourg, Strasbourg, France.
- 82 Neurosurgery Service, CHU de Strasbourg, Strasbourg, France.
- 83 Department of Radiology, Interventional Neuroradiology Service, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
- 84 Department of Radiology, Interventional Neuroradiology Service, CHU de Clermont-Ferrand, Clermont-Ferrand, France.
- 85 Department of Radiology, Interventional Neuroradiology Service, CHU de Limoges, Limoges, France.
- 86 Neurosurgery Service, CHU de Limoges, Limoges, France.
- 87 Department of Radiology, Interventional Neuroradiology Service, CHU de Dijon, Dijon, France.
- 88 Neurosurgery Service, CHU de Dijon, Dijon, France.
- 89 Department of Radiology, Interventional Neuroradiology Service, Boston Medical Centre, Boston, United States.
- 90 Department of Radiology, Interventional Neuroradiology Service, Mayo Clinics, Jacksonville, United States.
- 91 Neurosurgery Service, Mayo Clinics, Jacksonville, United States.
- 92 Neurosurgery Service, University of New Mexico Health Sciences Center, New Mexico, USA.
- 93 Neurology Department, Universidade Federal de São Paulo, São Paulo, Brazil.
- 94 Interventional Neuroradiology Service, Hospital Geral de Fortaleza, Fortaleza, Brazil.
- 95 Interventional Neuroradiology Service, Instituto de Neurocirugia Dr Alfonso Asenjo, Santiago, Chile.
- PMID: 36738962
- DOI: 10.1016/j.wneu.2023.01.098
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Abstract
Background: The Treatment of Brain Arteriovenous Malformations Study (TOBAS) is an all-inclusive pragmatic study comprising 2 randomized clinical trials (RCTs). Patients excluded from the RCTs are followed in parallel treatment and observation registries, allowing a comparison between RCT and registry patients.
Methods: The first randomized clinical trial (RCT-1) offers 1:1 randomized allocation of intervention versus conservative management for patients with arteriovenous malformation (AVM). The second randomized clinical trial (RCT-2) allocates 1:1 pre-embolization or no pre-embolization to surgery or radiosurgery patients judged treatable with or without embolization. Characteristics of RCT patients are reported and compared to registry patients.
Results: From June 2014 to May 2021, 1010 patients with AVM were recruited; 498 patients were observed and 373 were included in the treatment registries. Randomized allocation in RCT-1 was applied to 139 (26%) of the 512 patients (including 127 of 222 [57%] with unruptured AVMs) considered for curative treatment. RCT-1 AVM patients differed (in rupture status, Spetzler-Martin grade and baseline modified Rankin Score) from those in the observation or treatment registries (P < 0.001). Most patients had small (<3 cm; 71%) low-grade (Spetzler-Martin I-II; 64%) unruptured (91%) AVMs. The allocated management was conservative (n = 71) or curative (n = 68), using surgery (n = 39), embolization (n = 16), or stereotactic radiosurgery (n = 13). Pre-embolization was considered for 179/309 (58%) patients allocated/assigned to surgery or stereotactic radiosurgery; 87/179 (49%) were included in RCT-2. RCT-2 patient AVMs differed in size, eloquence and grade from patients of the pre-embolization registry (P < 0.01). Most had small (<3 cm in 82%) low-grade (83%) AVMs in non-eloquent brain (64%).
Conclusions: Patients included in the RCTs differ significantly from registry patients. Meaningful results can be obtained if multiple centers actively participate in the TOBAS RCTs.
Keywords: Brain arteriovenous malformation; Embolization; Pragmatic trials; Randomized trial.
Copyright © 2023 Elsevier Inc. All rights reserved.
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