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. 2023 Feb 4;13(1):2041.
doi: 10.1038/s41598-023-29071-4.

Association between urinary iodine concentration and the risk of papillary thyroid cancer by sex and age: a case-control study

Yerin Hwang  1 , Hyun-Kyung Oh  2 , Jae Hoon Chung  3 , Sun Wook Kim  3 , Jung-Han Kim  4 , Jee Soo Kim  4 , Myung-Hee Shin  5
Affiliations

Association between urinary iodine concentration and the risk of papillary thyroid cancer by sex and age: a case-control study

Yerin Hwang et al. Sci Rep. .

Abstract

Previous studies on dietary iodine intake and the risk of papillary thyroid cancer (PTC) have demonstrated inconsistent results. We aimed to evaluate the association between urinary iodine concentration (UIC), a surrogate biomarker for dietary iodine intake, and the risk of thyroid cancer stratified by sex and age in an iodine-sufficient area. A hospital-based case-control study was conducted in Seoul, South Korea. A total of 492 cases of newly diagnosed PTC and 595 controls were included. Compared with the lowest quartile of creatine-adjusted UIC (< 159.3 μg/gCr), the highest quartile (≥ 1037.3 μg/gCr) showed an increased risk of PTC (odds ratio [OR] 1.49, 95% confidence interval [CI] 1.04-2.13), especially in those who were < 45 years old (ptrend = 0.01) compared with those who were ≥ 45 years old (ptrend = 0.48). For those who were < 45 years old, a positive association between creatinine-adjusted UIC and the risk of PTC was observed in both men (q4 vs. q1, OR 4.27, 95% CI 1.14-18.08) and women (OR 1.97, 95% CI 1.04-3.78). For those who were ≥ 45 years old, no association was found in any sex. Creatinine-adjusted UIC was positively associated with the risk of PTC, especially in those who were younger than 45 years for both men and women.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Recruitment of case–control study participants and study flow chart.
See this image and copyright information in PMC

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