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Published Erratum
. 2023 Feb;299(2):102951.
doi: 10.1016/j.jbc.2023.102951. Epub 2023 Feb 4.

Correction: A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement

Rasmus K Jensen, Rasmus Pihl, Trine A F Gadeberg, Jan K Jensen, Kasper R Andersen, Steffen Thiel, Nick S Laursen, Gregers R Andersen
Published Erratum

Correction: A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement

Rasmus K Jensen et al. J Biol Chem. 2023 Feb.
No abstract available

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Figures

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Figure 1. The hC3Nb1 nanobody does not interact with native complement C3, but does interact with protease activated complement C3b. To analyze the interaction between hC3Nb1 and the control nanobody hC3Nb2 (4) with C3 or C3b, nanobody at 10 μg/mL was immobilized on anti-penta his (His1K) biosensors (Sartorius). The sensors were transferred into 50 nM C3 (left) or C3b (right) for 180 seconds, followed by a 180 seconds dissociation period. The sensorgrams were normalized by subtracting sensorgrams recorded without C3 and C3b.
See this image and copyright information in PMC

Erratum for

References

    1. Jensen R.K., Pihl R., Gadeberg T.A.F., Jensen J.K., Andersen K.R., Thiel S., Laursen N.S., Andersen G.R. A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement. J Biol Chem. 2018;293:6269–6281. - PMC - PubMed
    1. Pedersen D.V., Gadeberg T.A.F., Thomas C., Wang Y., Joram N., Jensen R.K., Mazarakis S.M.M., Revel M., El Sissy C., Petersen S.V., Lindorff-Larsen K., Thiel S., Laursen N.S., Fremeaux-Bacchi V., Andersen G.R. Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System. Front Immunol. 2019;10:2007. - PMC - PubMed
    1. Pedersen H., Jensen R.K., Hansen A.G., Petersen S.V., Thiel S., Laursen N.S., Andersen G.R. Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity. Frontiers in Immunology. 2022;13 - PMC - PubMed
    1. Pedersen H., Jensen R.K., Hansen A.G., Gadeberg T.A.F., Thiel S., Laursen N.S., Andersen G.R. A C3-specific nanobody that blocks all three activation pathways in the human and murine complement system. J Biol Chem. 2020;295:8746–8758. - PMC - PubMed

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