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Review
. 2023 Feb 5;23(1):19.
doi: 10.1186/s12935-023-02865-2.

Molecular mechanisms of microRNA-216a during tumor progression

Amir Abbas Hamidi  1 , Negin Taghehchian  2 , Amir Sadra Zangouei  1 , Iman Akhlaghipour  1 , Amirhosein Maharati  1 , Zahra Basirat  2 , Meysam Moghbeli  3   4
Affiliations
Review

Molecular mechanisms of microRNA-216a during tumor progression

Amir Abbas Hamidi et al. Cancer Cell Int. .

Abstract

MicroRNAs (miRNAs) as the members of non-coding RNAs family are involved in post-transcriptional regulation by translational inhibiting or mRNA degradation. They have a critical role in regulation of cell proliferation and migration. MiRNAs aberrations have been reported in various cancers. Considering the importance of these factors in regulation of cellular processes and their high stability in body fluids, these factors can be suggested as suitable non-invasive markers for the cancer diagnosis. MiR-216a deregulation has been frequently reported in different cancers. Therefore, in the present review we discussed the molecular mechanisms of the miR-216a during tumor progression. It has been reported that miR-216a mainly functioned as a tumor suppressor through the regulation of signaling pathways and transcription factors. This review paves the way to suggest the miR-216a as a probable therapeutic and diagnostic target in cancer patients.

Keywords: Cancer; Diagnosis; Marker; MicroRNA-216a; Prognosis; Treatment.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Role of miR-216a during tumor progression by regulation of JAK/STAT, MAPK, and Hippo signaling pathways. (Created with BioRender.com)
Fig. 2
Fig. 2
Role of miR-216a during tumor progression by regulation of PI3K/AKT and TGF-β signaling pathways. (Created with BioRender.com)
Fig. 3
Fig. 3
Role of miR-216a during tumor progression by regulation of transcription factors. (Created with BioRender.com)
Fig. 4
Fig. 4
Role of miR-216a during tumor progression by regulation of apoptosis and autophagy. (Created with BioRender.com)
Fig. 5
Fig. 5
Role of miR-216a during tumor progression by regulation of structural proteins involved in cell adhesion, metabolism, DNA repair, and immune response. (Created with BioRender.com)
See this image and copyright information in PMC

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