Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jan 27:21:13.
doi: 10.18332/tid/156047. eCollection 2023.

How does cigarette smoking affect airway remodeling in asthmatics?

Huihui Lin  1 , Hequan Li  1
Affiliations
Review

How does cigarette smoking affect airway remodeling in asthmatics?

Huihui Lin et al. Tob Induc Dis. .

Abstract

Asthma is a prevalent chronic airway inflammatory disease involving multiple cells, and the prolonged course of the disease can cause airway remodeling, resulting in irreversible or partial irreversible airflow limitation and persistent airway hyperresponsiveness (AHR) in asthmatics. Therefore, we must ascertain the factors that affect the occurrence and development of airway remodeling in asthmatics. Smokers are not uncommon in asthmatics. However, there is no systematic description of how smoking promotes airway remodeling in asthmatics. This narrative review summarizes the effects of smoking on airway remodeling in asthmatics, and the progress of the methods for evaluating airway remodeling.

Keywords: airway inflammation; airway remodeling; asthma; cigarette smoking.

PubMed Disclaimer

Conflict of interest statement

The authors have each completed and submitted an ICMJE form for disclosure of potential conflicts of interest. The authors declare that they have no competing interests, financial or otherwise, related to the current work. Both authors report that since the initial planning of the work, this study was supported from National Natural Science Foundation of China (Grand Number 81970015).

Figures

Figure 1
Figure 1
Effects of CSE on airway remodeling in asthma from the perspective of airway inflammation
Figure 2
Figure 2
Effects of CSE on airway remodeling in asthma from the perspective of airway damage repair
Figure 3
Figure 3
Software assessment of airway remodeling
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. GBD 2017 Causes of Death Collaborators Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1736–1788. doi: 10.1016/S0140-6736(18)32203-7. - DOI - PMC - PubMed
    1. Sutherland ER, Martin RJ. Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma. J Allergy Clin Immunol. 2003;112(5):819–828. doi: 10.1016/S0091. - DOI - PubMed
    1. Huang K, Yang T, Xu J, et al. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study. Lancet. 2019;394(10196):407–418. doi: 10.1016/S0140-6736(19)31147-X. - DOI - PubMed
    1. Thomson NC, Chaudhuri R, Livingston E. Asthma and cigarette smoking. Eur Respir J. 2004;24(5):822–833. doi: 10.1183/09031936.04.00039004. - DOI - PubMed
    1. Oczypok EA, Milutinovic PS, Alcorn JF, et al. Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells. J Allergy Clin Immunol. 2015;136(3):747–756.e4. doi: 10.1016/j.jaci.2015.03.011. - DOI - PMC - PubMed

LinkOut - more resources