Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2023 Jan 6:10:1.
doi: 10.21037/sci-2022-047. eCollection 2023.

A selective type of autophagy to maintain glioma stem cell activity

Affiliations
Editorial

A selective type of autophagy to maintain glioma stem cell activity

Khushbu Patel et al. Stem Cell Investig. .
No abstract available

Keywords: Chaperone-mediated autophagy (CMA); glioblastoma; proteostasis; stem cell.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://sci.amegroups.com/article/view/10.21037/sci-2022-047/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Representation of the multiple processes trough which CMA is proposed to control GSC activity. CMA, chaperone-mediated autophagy; ECM, extracellular matrix; GSC, glioblastoma stem cell population.

Comment on

References

    1. Salinas MD, Valdor R. Chaperone-Mediated Autophagy in Pericytes: A Key Target for the Development of New Treatments against Glioblastoma Progression. Int J Mol Sci 2022;23:8886. 10.3390/ijms23168886 - DOI - PMC - PubMed
    1. Arias E, Cuervo AM. Chaperone-mediated autophagy in protein quality control. Curr Opin Cell Biol 2011;23:184-9. 10.1016/j.ceb.2010.10.009 - DOI - PMC - PubMed
    1. Arias E, Koga H, Diaz A, et al. Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy. Mol Cell 2015;59:270-84. 10.1016/j.molcel.2015.05.030 - DOI - PMC - PubMed
    1. Arias E. Lysosomal mTORC2/PHLPP1/Akt axis: a new point of control of chaperone-mediated autophagy. Oncotarget 2015;6:35147-8. 10.18632/oncotarget.5903 - DOI - PMC - PubMed
    1. Arias E, Cuervo AM. Pros and Cons of Chaperone-Mediated Autophagy in Cancer Biology. Trends Endocrinol Metab 2020;31:53-66. 10.1016/j.tem.2019.09.007 - DOI - PMC - PubMed