Can salivary microbiome become a biodetector for type-2 diabetes? Opinion for future implications and strategies

Affiliations

¹ Division of Applied Nutrition, Faculty of Human Ecology, Department of Community Nutrition, IPB University, Bogor, Indonesia.
² Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga Yogyakarta), Yogyakarta, Indonesia.
³ Alumnus of Department of Internal Medicine, Faculty of Medicine, University of Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
⁴ Alumnus of Department of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
⁵ Medical Study Programme, Faculty of Medicine, Brawijaya University, Malang, Indonesia.
⁶ Medical Student of Faculty of Medicine, University of Jember-Soebandi Regional Hospital, Jember, Indonesia.
⁷ Medical Student of Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

PMID: 36742425
PMCID: PMC9892936
DOI: 10.3389/fnut.2023.1113591

Can salivary microbiome become a biodetector for type-2 diabetes? Opinion for future implications and strategies

Hardinsyah Hardinsyah et al. Front Nutr. 2023.

. 2023 Jan 19:10:1113591.

doi: 10.3389/fnut.2023.1113591. eCollection 2023.

Affiliations

¹ Division of Applied Nutrition, Faculty of Human Ecology, Department of Community Nutrition, IPB University, Bogor, Indonesia.
² Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga Yogyakarta), Yogyakarta, Indonesia.
³ Alumnus of Department of Internal Medicine, Faculty of Medicine, University of Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
⁴ Alumnus of Department of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
⁵ Medical Study Programme, Faculty of Medicine, Brawijaya University, Malang, Indonesia.
⁶ Medical Student of Faculty of Medicine, University of Jember-Soebandi Regional Hospital, Jember, Indonesia.
⁷ Medical Student of Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

PMID: 36742425
PMCID: PMC9892936
DOI: 10.3389/fnut.2023.1113591

No abstract available

Keywords: T2DM; biodetector; diabetes; oral microbiome; salivary bacterial.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

**FIGURE 1**
Salivary microbiome as a potential biodetector for type 2 diabetes mellitus (T2DM). Created with BioRender.com premium license by Fahrul Nurkolis.

See this image and copyright information in PMC

Cited by

Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population.
Zeng X, Huang S, Ye X, Song S, He J, Hu L, Deng S, Liu F. Zeng X, et al. J Oral Microbiol. 2024 May 15;16(1):2345942. doi: 10.1080/20002297.2024.2345942. eCollection 2024. J Oral Microbiol. 2024. PMID: 38756148 Free PMC article.
Salivary proteomics and metaproteomics identifies distinct molecular and taxonomic signatures of type-2 diabetes.
Samodova D, Stankevic E, Søndergaard MS, Hu N, Ahluwalia TS, Witte DR, Belstrøm D, Lubberding AF, Jagtap PD, Hansen T, Deshmukh AS. Samodova D, et al. Microbiome. 2025 Jan 10;13(1):5. doi: 10.1186/s40168-024-01997-5. Microbiome. 2025. PMID: 39794871 Free PMC article.
Salivary microbiota and IgA responses are different in pre-diabetic individuals compared to normoglycemic controls.
Kato-Kogoe N, Tsuda K, Kudo A, Sakaguchi S, Omori M, Komori E, Ohmichi M, Hamada W, Nakamura S, Nakano T, Tamaki J, Ueno T. Kato-Kogoe N, et al. Front Cell Infect Microbiol. 2025 Jun 4;15:1591285. doi: 10.3389/fcimb.2025.1591285. eCollection 2025. Front Cell Infect Microbiol. 2025. PMID: 40535541 Free PMC article.

References

1. Berg G, Rybakova D, Fischer D, Cernava T, Vergès M, Charles T, et al. Microbiome definition re-visited: old concepts and new challenges. Microbiome. (2020) 8:103. 10.1186/s40168-020-00875-0 - DOI - PMC - PubMed
1. Rajagopala SV, Vashee S, Oldfield L, Suzuki Y, Venter J, Telenti A, et al. The human microbiome and cancer. Cancer Prev Res (Phila). (2017) 10:226–34. 10.1158/1940-6207.CAPR-16-0249 - DOI - PubMed
1. Coker O. Non-bacteria microbiome (virus, fungi, and archaea) in gastrointestinal cancer. J Gastroenterol Hepatol. (2022) 37:256–62. 10.1111/jgh.15738 - DOI - PubMed
1. Valdes A, Walter J, Segal E, Spector T. Role of the gut microbiota in nutrition and health. BMJ. (2018) 361:k2179. 10.1136/bmj.k2179 - DOI - PMC - PubMed
1. Deo P, Deshmukh R. Oral microbiome: unveiling the fundamentals. J Oral Maxillofac Pathol JOMFP. (2019) 23:122–8. 10.4103/jomfp.JOMFP_152_19 - DOI - PMC - PubMed

LinkOut - more resources

Full Text Sources

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Can salivary microbiome become a biodetector for type-2 diabetes? Opinion for future implications and strategies

Affiliations

Can salivary microbiome become a biodetector for type-2 diabetes? Opinion for future implications and strategies

Authors

Affiliations

Conflict of interest statement

Figures

Similar articles

Cited by

References

LinkOut - more resources

Full Text Sources