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. 2022 Dec;74(Suppl 3):3582-3588.
doi: 10.1007/s12070-020-01996-6. Epub 2020 Jul 25.

Comparison of Palonosetron with Combination of Palonosetron and Dexamethasone in the Prevention of Post Operative Nausea and Vomiting in Patients Undergoing Middle Ear Surgery: A Prospective Randomized Trial

Neeru Sahni  1 , Nidhi Panda  1 , Amit Kumar  1 , Indu Bala  1 , Naresh Panda  2
Affiliations

Comparison of Palonosetron with Combination of Palonosetron and Dexamethasone in the Prevention of Post Operative Nausea and Vomiting in Patients Undergoing Middle Ear Surgery: A Prospective Randomized Trial

Neeru Sahni et al. Indian J Otolaryngol Head Neck Surg. 2022 Dec.

Abstract

We compared the use of palonosetron with combination of palonosetron and dexamethasone in prevention of PONV in patients undergoing middle ear surgery under general anaesthesia. Prospective, randomized study was conducted including 90 adult patients who received either palonosetron (0.075 mg) (Group P) or combination of palonosetron (0.075 mg) and dexamethasone (8 mg) (Group PD). The primary outcome was incidence of nausea, vomiting and complete response. Secondary parameters were time to receive first rescue antiemetic, total dose required, patient's satisfaction, postoperative pain scores and total dose of rescue analgesic. The incidence of nausea was 15.5% and 8.8% (p = 0.522) and vomiting was 6.7% and 2.2% (p = 0.610) in group P and PD, respectively Complete response (CR) was observed in 84.4% patients in group P and 91% patients in group PD (p = 0.522). Combination of palonosetron and dexamethasone is not superior to use of palonosetron alone for PONV prevention.

Keywords: Antiemetics; Nausea and vomiting; Otologic surgery; Postoperative; Steroids.

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Conflict of interest statement

Conflict of interestAuthors: Neeru Sahni, Nidhi Panda, Amit Kumar, Indu Bala and Naresh Panda report no conflict of interest.

Figures

Fig. 1
Fig. 1
CONSORT diagram
See this image and copyright information in PMC

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