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. 2022 Dec;74(Suppl 3):6048-6053.
doi: 10.1007/s12070-021-02698-3. Epub 2021 Jun 27.

Prognosis and Outcomes in Early Stage Glottic Carcinoma Involving the Anterior Commissure Treated with Laser CO2 Surgery: A Retrospective Observational Analysis

A Carreras  1 , M I Martínez-Torre  2 , M Zabaleta  2 , A Sanchez-Del-Rey  3 , F Santaolalla  3 , P Diaz-de-Cerio  2
Affiliations

Prognosis and Outcomes in Early Stage Glottic Carcinoma Involving the Anterior Commissure Treated with Laser CO2 Surgery: A Retrospective Observational Analysis

A Carreras et al. Indian J Otolaryngol Head Neck Surg. 2022 Dec.

Abstract

The anterior commissure (AC) is the area where the vocal cords attach to the thyroid cartilage through Broyles' ligament. Many authors argue that involvement of the anterior commissure in early stage glottic carcinoma (I, II) constitutes a risk factor for local recurrence. The objective of this study is to evaluate whether anterior commissure involvement in early stage glottis cancer is an independent risk factor for recurrence and mortality. The study included all those patients diagnosed with glottis carcinoma in stages I and II of the AJCC treated by transoral laser surgery at the Hospital San Pedro (Logroño, Spain) between 2005 and 2015. Patients were divided into two groups according to the presence (AC1) or absence (AC0) of involvement of the commissure. Of 29 patients treated, 44.8% were AC1. Patients with anterior commissure involvement had more local recurrence (p = 0.2701); higher mortality rate (p = 0.2256); lower disease-free survival (p = 0.0881) and a lower overall survival (p = 0.0331). The 5-year survival rate was 24.5% lower in patients with invasion of the anterior commissure. The involvement of the anterior commissure is an independent risk factor that should be considered in the prognosis of laryngeal cancer.

Keywords: Anterior commissure; CO2 laser; Glottis; Laryngeal neoplasms; Vocal cords.

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Conflict of interest statement

Conflict of interestAll authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Disease-free survival
Fig. 2
Fig. 2
Mean survival rate
See this image and copyright information in PMC

References

    1. Gómez GJ, Bernal M, Bezerra DL, Rodríguez EE, Reboreda A, Hernández R. Trends in laryngeal cancer incidence in a health area between 2007 and 2013. Acta Otorrinolaringol Esp. 2015;66(3):127–131. - PubMed
    1. Hoffman HT, Iseli TA, Karnell LH, McCulloch TM, Buatti JM, Funk GF (2010) Management of early glottic cancer. In: Cummings otolaryngology head and neck surgery. Elsevier-Mosby, Philadelphia
    1. Koch WM, Machtay M, Best S (2016) Treatment of early (stage I and II) head and neck cancer: the larynx. In: UpToDate. Basow DS Waltham
    1. Steiner W, Vogt P, Ambrosch P, Kron M. Transoral carbon dioxide laser microsurgery for recurrent glottic carcinoma after radiotherapy. Head Neck. 2004;26(6):477–484. doi: 10.1002/hed.20009. - DOI - PubMed
    1. González-García JA, Rodríguez Paramás A, Souvirón Encabo R, Ortiz García P, Scola YB. Treatment of early glottic carcinoma with transoral laser CO2. Acta Otorrinolaringol Esp. 2006;57(8):364–368. doi: 10.1016/S0001-6519(06)78729-5. - DOI - PubMed

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