Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jan 25;12(1):1-11.
doi: 10.5501/wjv.v12.i1.1.

Joint replacement and human immunodeficiency virus

Maryam Salimi  1 , Peyman Mirghaderi  2 , Seyedarad Mosalamiaghili  3 , Ali Mohammadi  3 , Amirhossein Salimi  4
Affiliations
Review

Joint replacement and human immunodeficiency virus

Maryam Salimi et al. World J Virol. .

Abstract

The incidence of human immunodeficiency virus (HIV)-infected cases that need total joint replacement (TJR) is generally rising. On the other hand, modern management of HIV-infected cases has enabled them to achieve longevity while increasing the need for arthroplasty procedures due to the augmented dege-nerative joint disease and fragility fractures, and the risk of osteonecrosis. Although initial investigations on joint replacement in HIV-infected cases showed a high risk of complications, the recent ones reported acceptable outcomes. It is a matter of debate whether HIV-infected cases are at advanced risk for adverse TJR consequences; however, the weak immune profile has been associated with an increased probability of complications. Likewise, surgeons and physicians should be aware of the complication rate after TJR in HIV-infected cases and include an honest discussion of the probable unwelcoming complication with their patients contemplating TJR. Therefore, a fundamental review and understanding of the interaction of HIV and arthroplasty are critical.

Keywords: Arthroplasty; Human immunodeficiency virus; Infection; Joint replacement.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: There is no conflict of interest associated with any of the senior authors or other coauthors who contributed their efforts to this manuscript.

Figures

Figure 1
Figure 1
Factors affecting joint replacement among human immunodeficiency virus-positive patients. HIV: Human immunodeficiency virus; THA: Total hip arthroplasty.
See this image and copyright information in PMC

References

    1. Dimitriou D, Ramokgopa M, Pietrzak JRT, van der Jagt D, Mokete L. Human Immunodeficiency Virus Infection and Hip and Knee Arthroplasty. JBJS Rev . 2017;5:e8. - PubMed
    1. Mirghaderi SP, Sharifpour S, Moharrami A, Ahmadi N, Makuku R, Salimi M, Mortazavi SMJ. Determining the accuracy of preoperative total hip replacement 2D templating using the mediCAD® software. J Orthop Surg Res . 2022;17:222. - PMC - PubMed
    1. Pietrzak JRT, Maharaj Z, Mokete L, Sikhauli N. Human immunodeficiency virus in total hip arthroplasty. EFORT Open Rev . 2020;5:164–171. - PMC - PubMed
    1. Permpalung N, Ungprasert P, Summachiwakij S, Leeaphorn N, Knight EL. Protease inhibitors and avascular necrosis: a systematic review and meta-analysis. Int J Antimicrob Agents . 2014;44:93–95. - PubMed
    1. Molia AC, Strady C, Rouger C, Beguinot IM, Berger JL, Trenque TC. Osteonecrosis in six HIV-infected patients receiving highly active antiretroviral therapy. Ann Pharmacother . 2004;38:2050–2054. - PubMed